Reduction of infection frequency by intravenous gammaglobulins during intensive induction therapy for small cell carcinoma of the lung

Thirty-two patients with small cell carcinoma of the lung received intensive induction chemoradiotherapy. In a randomized prospective study, we compared the outcome of patients who received 30 g immunoglobulin i.v. divided into three doses per therapy course for infection prophylaxis (Group A) with...

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Bibliographic Details
Published in:Infection 1984-05, Vol.12 (3), p.167-170
Main Authors: SCHMIDT, R. E, HARTLAPP, J. H, NIESE, D, ILLIGER, H. J, STROEHMANN, I
Format: Article
Language:English
Subjects:
Adult
Aged
Bacterial Infections - complications
Bacterial Infections - prevention & control
Biological and medical sciences
Carcinoma, Small Cell - complications
Carcinoma, Small Cell - immunology
Carcinoma, Small Cell - therapy
Combined Modality Therapy
Female
Humans
Immune Tolerance
Immunoglobulin G - analogs & derivatives
Immunoglobulin G - analysis
Immunoglobulin G - therapeutic use
Immunoglobulins, Intravenous
Lung Neoplasms - complications
Lung Neoplasms - immunology
Lung Neoplasms - therapy
Male
Medical sciences
Middle Aged
Pneumology
Prospective Studies
Tumors of the respiratory system and mediastinum
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Summary:Thirty-two patients with small cell carcinoma of the lung received intensive induction chemoradiotherapy. In a randomized prospective study, we compared the outcome of patients who received 30 g immunoglobulin i.v. divided into three doses per therapy course for infection prophylaxis (Group A) with patients undergoing the same anti-tumor therapy (Group B). All patients were prospectively randomized to one of two groups in order to evaluate the role of intravenous immunoglobulin therapy for infection prophylaxis. Group A received 30 g intravenous immunoglobulin during each course of chemotherapy. Group B was a control group that received identical chemoradiotherapy but did not receive any immunoglobulin therapy. All patients had a severely impaired cellular immune response. IgG serum concentrations were significantly higher in group A. Patients who received intravenous immunoglobulin had significantly fewer infections during the entire treatment period than patients who did not receive prophylactic treatment.
ISSN:0300-8126
1439-0973
DOI:10.1007/BF01640891