Measurement of Blood-Brain Barrier Permeability with Positron Emission Tomography and [ Ga]EDTA

Positron emission tomography (PET) was employed to examine time-dependent changes in blood–brain barrier (BBB) permeability to [68Ga]ethylenediaminetetraacetate (EDTA) in the rhesus monkey, following reversible barrier opening by intracarotid infusion of a hypertonic mannitol solution. The PET techn...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Cerebral Blood Flow & Metabolism 1984-09, Vol.4 (3), p.323-328
Main Authors: Kessler, R. M., Goble, J. C., Bird, J. H., Girton, M. E., Doppman, J. L., Rapoport, S. I., Barranger, J. A.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood-Brain Barrier
Capillary Permeability
Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges
Edetic Acid
Fundamental and applied biological sciences. Psychology
Gallium Radioisotopes
Macaca mulatta
Models, Biological
Tomography, Emission-Computed
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c444t-fe97e2b1ba9ee03cade3d870192e8f85e29a738aa25b21eb7f2a0b9a54f230613
cites cdi_FETCH-LOGICAL-c444t-fe97e2b1ba9ee03cade3d870192e8f85e29a738aa25b21eb7f2a0b9a54f230613
container_end_page 328
container_issue 3
container_start_page 323
container_title Journal of Cerebral Blood Flow & Metabolism
container_volume 4
creator Kessler, R. M.
Goble, J. C.
Bird, J. H.
Girton, M. E.
Doppman, J. L.
Rapoport, S. I.
Barranger, J. A.
description Positron emission tomography (PET) was employed to examine time-dependent changes in blood–brain barrier (BBB) permeability to [68Ga]ethylenediaminetetraacetate (EDTA) in the rhesus monkey, following reversible barrier opening by intracarotid infusion of a hypertonic mannitol solution. The PET technique, when combined with measurements of plasma radioactivity, provided a quantitative measure of the cerebrovascular permeability-area product (PA) at different times following mannitol infusion. Hypertonic mannitol treatment reversibly increased PA to [68Ga]EDTA more than 10-fold; much of the barrier effect was over by 10 min after mannitol treatment. The results show that PET can be used to measure transient changes in BBB integrity in specific brain regions, under in vivo, noninvasive conditions.
doi_str_mv 10.1038/jcbfm.1984.48
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_81203343</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1038_jcbfm.1984.48</sage_id><sourcerecordid>81203343</sourcerecordid><originalsourceid>FETCH-LOGICAL-c444t-fe97e2b1ba9ee03cade3d870192e8f85e29a738aa25b21eb7f2a0b9a54f230613</originalsourceid><addsrcrecordid>eNp1kU1r3DAQhkVJSLZpjz0GFCg9FLzVl235mE23aSChOWyhUIoY26NEi21tJZuy_77a7LK3nDQwD-9oniHkA2dzzqT-sm5q2895pdVc6TdkxvO8ykrGixMyY6LkWVHqX-fkbYxrxpiWeX5GzgolhWbFjJgHhDgF7HEYqbd00XnfZosAbqALCMFhoI8YeoTadW7c0n9ufKaPProx-IEuexejS8XK9_4pwOZ5S2Fo6W96C3-WX1fX78iphS7i-8N7QX5-W65uvmf3P27vbq7vs0YpNWYWqxJFzWuoEJlsoEXZ6rRFJVBbnaOooJQaQOS14FiXVgCrK8iVFZIVXF6QT_vcTfB_J4yjST9rsOtgQD9Fo7lgUiqZwGwPNsHHGNCaTXA9hK3hzOyEmhehZifUKJ34y0PwVPfYHumDwdT_eOhDbKCzAYbGxSNWpR202MV83mMRntCs_RSGpOPVmVd7eIAx3eYY9kLtoMT8B0bwmHM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>81203343</pqid></control><display><type>article</type><title>Measurement of Blood-Brain Barrier Permeability with Positron Emission Tomography and [ Ga]EDTA</title><source>SAGE Journals Online Archive</source><creator>Kessler, R. M. ; Goble, J. C. ; Bird, J. H. ; Girton, M. E. ; Doppman, J. L. ; Rapoport, S. I. ; Barranger, J. A.</creator><creatorcontrib>Kessler, R. M. ; Goble, J. C. ; Bird, J. H. ; Girton, M. E. ; Doppman, J. L. ; Rapoport, S. I. ; Barranger, J. A.</creatorcontrib><description>Positron emission tomography (PET) was employed to examine time-dependent changes in blood–brain barrier (BBB) permeability to [68Ga]ethylenediaminetetraacetate (EDTA) in the rhesus monkey, following reversible barrier opening by intracarotid infusion of a hypertonic mannitol solution. The PET technique, when combined with measurements of plasma radioactivity, provided a quantitative measure of the cerebrovascular permeability-area product (PA) at different times following mannitol infusion. Hypertonic mannitol treatment reversibly increased PA to [68Ga]EDTA more than 10-fold; much of the barrier effect was over by 10 min after mannitol treatment. The results show that PET can be used to measure transient changes in BBB integrity in specific brain regions, under in vivo, noninvasive conditions.</description><identifier>ISSN: 0271-678X</identifier><identifier>EISSN: 1559-7016</identifier><identifier>DOI: 10.1038/jcbfm.1984.48</identifier><identifier>PMID: 6432806</identifier><identifier>CODEN: JCBMDN</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Biological and medical sciences ; Blood-Brain Barrier ; Capillary Permeability ; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges ; Edetic Acid ; Fundamental and applied biological sciences. Psychology ; Gallium Radioisotopes ; Macaca mulatta ; Models, Biological ; Tomography, Emission-Computed ; Vertebrates: nervous system and sense organs</subject><ispartof>Journal of Cerebral Blood Flow &amp; Metabolism, 1984-09, Vol.4 (3), p.323-328</ispartof><rights>1984 International Society for Cerebral Blood Flow and Metabolism</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-fe97e2b1ba9ee03cade3d870192e8f85e29a738aa25b21eb7f2a0b9a54f230613</citedby><cites>FETCH-LOGICAL-c444t-fe97e2b1ba9ee03cade3d870192e8f85e29a738aa25b21eb7f2a0b9a54f230613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1984.48$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1038/jcbfm.1984.48$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>313,314,780,784,792,21860,27922,27924,27925,44857,45245</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=9701828$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6432806$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kessler, R. M.</creatorcontrib><creatorcontrib>Goble, J. C.</creatorcontrib><creatorcontrib>Bird, J. H.</creatorcontrib><creatorcontrib>Girton, M. E.</creatorcontrib><creatorcontrib>Doppman, J. L.</creatorcontrib><creatorcontrib>Rapoport, S. I.</creatorcontrib><creatorcontrib>Barranger, J. A.</creatorcontrib><title>Measurement of Blood-Brain Barrier Permeability with Positron Emission Tomography and [ Ga]EDTA</title><title>Journal of Cerebral Blood Flow &amp; Metabolism</title><addtitle>J Cereb Blood Flow Metab</addtitle><description>Positron emission tomography (PET) was employed to examine time-dependent changes in blood–brain barrier (BBB) permeability to [68Ga]ethylenediaminetetraacetate (EDTA) in the rhesus monkey, following reversible barrier opening by intracarotid infusion of a hypertonic mannitol solution. The PET technique, when combined with measurements of plasma radioactivity, provided a quantitative measure of the cerebrovascular permeability-area product (PA) at different times following mannitol infusion. Hypertonic mannitol treatment reversibly increased PA to [68Ga]EDTA more than 10-fold; much of the barrier effect was over by 10 min after mannitol treatment. The results show that PET can be used to measure transient changes in BBB integrity in specific brain regions, under in vivo, noninvasive conditions.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood-Brain Barrier</subject><subject>Capillary Permeability</subject><subject>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</subject><subject>Edetic Acid</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gallium Radioisotopes</subject><subject>Macaca mulatta</subject><subject>Models, Biological</subject><subject>Tomography, Emission-Computed</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0271-678X</issn><issn>1559-7016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><recordid>eNp1kU1r3DAQhkVJSLZpjz0GFCg9FLzVl235mE23aSChOWyhUIoY26NEi21tJZuy_77a7LK3nDQwD-9oniHkA2dzzqT-sm5q2895pdVc6TdkxvO8ykrGixMyY6LkWVHqX-fkbYxrxpiWeX5GzgolhWbFjJgHhDgF7HEYqbd00XnfZosAbqALCMFhoI8YeoTadW7c0n9ufKaPProx-IEuexejS8XK9_4pwOZ5S2Fo6W96C3-WX1fX78iphS7i-8N7QX5-W65uvmf3P27vbq7vs0YpNWYWqxJFzWuoEJlsoEXZ6rRFJVBbnaOooJQaQOS14FiXVgCrK8iVFZIVXF6QT_vcTfB_J4yjST9rsOtgQD9Fo7lgUiqZwGwPNsHHGNCaTXA9hK3hzOyEmhehZifUKJ34y0PwVPfYHumDwdT_eOhDbKCzAYbGxSNWpR202MV83mMRntCs_RSGpOPVmVd7eIAx3eYY9kLtoMT8B0bwmHM</recordid><startdate>198409</startdate><enddate>198409</enddate><creator>Kessler, R. M.</creator><creator>Goble, J. C.</creator><creator>Bird, J. H.</creator><creator>Girton, M. E.</creator><creator>Doppman, J. L.</creator><creator>Rapoport, S. I.</creator><creator>Barranger, J. A.</creator><general>SAGE Publications</general><general>Lippincott Williams &amp; Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198409</creationdate><title>Measurement of Blood-Brain Barrier Permeability with Positron Emission Tomography and [ Ga]EDTA</title><author>Kessler, R. M. ; Goble, J. C. ; Bird, J. H. ; Girton, M. E. ; Doppman, J. L. ; Rapoport, S. I. ; Barranger, J. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-fe97e2b1ba9ee03cade3d870192e8f85e29a738aa25b21eb7f2a0b9a54f230613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood-Brain Barrier</topic><topic>Capillary Permeability</topic><topic>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</topic><topic>Edetic Acid</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gallium Radioisotopes</topic><topic>Macaca mulatta</topic><topic>Models, Biological</topic><topic>Tomography, Emission-Computed</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kessler, R. M.</creatorcontrib><creatorcontrib>Goble, J. C.</creatorcontrib><creatorcontrib>Bird, J. H.</creatorcontrib><creatorcontrib>Girton, M. E.</creatorcontrib><creatorcontrib>Doppman, J. L.</creatorcontrib><creatorcontrib>Rapoport, S. I.</creatorcontrib><creatorcontrib>Barranger, J. A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Cerebral Blood Flow &amp; Metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kessler, R. M.</au><au>Goble, J. C.</au><au>Bird, J. H.</au><au>Girton, M. E.</au><au>Doppman, J. L.</au><au>Rapoport, S. I.</au><au>Barranger, J. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measurement of Blood-Brain Barrier Permeability with Positron Emission Tomography and [ Ga]EDTA</atitle><jtitle>Journal of Cerebral Blood Flow &amp; Metabolism</jtitle><addtitle>J Cereb Blood Flow Metab</addtitle><date>1984-09</date><risdate>1984</risdate><volume>4</volume><issue>3</issue><spage>323</spage><epage>328</epage><pages>323-328</pages><issn>0271-678X</issn><eissn>1559-7016</eissn><coden>JCBMDN</coden><abstract>Positron emission tomography (PET) was employed to examine time-dependent changes in blood–brain barrier (BBB) permeability to [68Ga]ethylenediaminetetraacetate (EDTA) in the rhesus monkey, following reversible barrier opening by intracarotid infusion of a hypertonic mannitol solution. The PET technique, when combined with measurements of plasma radioactivity, provided a quantitative measure of the cerebrovascular permeability-area product (PA) at different times following mannitol infusion. Hypertonic mannitol treatment reversibly increased PA to [68Ga]EDTA more than 10-fold; much of the barrier effect was over by 10 min after mannitol treatment. The results show that PET can be used to measure transient changes in BBB integrity in specific brain regions, under in vivo, noninvasive conditions.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>6432806</pmid><doi>10.1038/jcbfm.1984.48</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0271-678X
ispartof Journal of Cerebral Blood Flow & Metabolism, 1984-09, Vol.4 (3), p.323-328
issn 0271-678X
1559-7016
language eng
recordid cdi_proquest_miscellaneous_81203343
source SAGE Journals Online Archive
subjects Animals
Biological and medical sciences
Blood-Brain Barrier
Capillary Permeability
Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges
Edetic Acid
Fundamental and applied biological sciences. Psychology
Gallium Radioisotopes
Macaca mulatta
Models, Biological
Tomography, Emission-Computed
Vertebrates: nervous system and sense organs
title Measurement of Blood-Brain Barrier Permeability with Positron Emission Tomography and [ Ga]EDTA
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T21%3A35%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Measurement%20of%20Blood-Brain%20Barrier%20Permeability%20with%20Positron%20Emission%20Tomography%20and%20%5B%20Ga%5DEDTA&rft.jtitle=Journal%20of%20Cerebral%20Blood%20Flow%20&%20Metabolism&rft.au=Kessler,%20R.%20M.&rft.date=1984-09&rft.volume=4&rft.issue=3&rft.spage=323&rft.epage=328&rft.pages=323-328&rft.issn=0271-678X&rft.eissn=1559-7016&rft.coden=JCBMDN&rft_id=info:doi/10.1038/jcbfm.1984.48&rft_dat=%3Cproquest_cross%3E81203343%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c444t-fe97e2b1ba9ee03cade3d870192e8f85e29a738aa25b21eb7f2a0b9a54f230613%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=81203343&rft_id=info:pmid/6432806&rft_sage_id=10.1038_jcbfm.1984.48&rfr_iscdi=true