Inhibition of Growth of Candida albicans by Iron-Unsaturated Lactoferrin: Relation to Host-Defense Mechanisms in Chronic Mucocutaneous Candidiasis

Since iron-binding proteins in serum and external secretions inhibit growth of certain microorganisms, the effect of lactoferrin on growth of Candida albicans was determined. The iron-unsaturated protein markedly impaired replication of the yeast, and the growth-inhibitory property was lost when lac...

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Bibliographic Details
Published in:The Journal of infectious diseases 1971-12, Vol.124 (6), p.539-544
Main Authors: Kirkpatrick, Charles H., Green, Ira, Rich, Robert R., Schade, Arthur L.
Format: Article
Language:English
Subjects:
Body Fluids - analysis
Body Fluids - immunology
Candida - drug effects
Candida albicans
Candida albicans - drug effects
Candidiasis
Candidiasis, Cutaneous - blood
Candidiasis, Cutaneous - immunology
Candidiasis, Cutaneous - metabolism
Cell Nucleus - metabolism
Chronic Disease
DNA
Fluorescent Antibody Technique
HeLa cells
Humans
Immunoelectrophoresis
Infections
Iron - metabolism
Iron - pharmacology
Iron binding proteins
Lactoglobulins - analysis
Lactoglobulins - blood
Lactoglobulins - pharmacology
Leukocytes - analysis
Leukocytes - immunology
Microorganisms
Neutrophils
Neutrophils - analysis
Original Articles
Parotid Gland - metabolism
Secretion
Yeasts
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Summary:Since iron-binding proteins in serum and external secretions inhibit growth of certain microorganisms, the effect of lactoferrin on growth of Candida albicans was determined. The iron-unsaturated protein markedly impaired replication of the yeast, and the growth-inhibitory property was lost when lactoferrin was saturated with iron. The content of lactoferrin in parotid fluids and leukocytes from patients with chronic mucocutaneous candidiasis was measured and compared to that of normal subjects. By immunofluorescence, lactoferrin was localized in the nuclei of band forms and mature polymorphonuclear neutrophiles. There were no differences in the distribution of lactoferrin in leukocytes from patients or controls, and the mean concentrations of lactoferrin in parotid fluids from the two groups were not different.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/124.6.539