Thetitration of isoniazid and other hydrazine derivatives with chloramine-t

Back-titration procedures with chloramine-T as the oxidant in 2 N acidic medium are described for the following compounds: hydrazine, phenylhydrazine, 2,4-dinitrophenylhydrazine, semicarbazide, p-nitrobenzhydrazide and isoniazid. In all cases, the oxidation, with consumption of 4 moles of chloramine...

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Bibliographic Details
Published in:Analytica chimica acta 1971-12, Vol.57 (2), p.429-434
Main Authors: Rajasekharan Nair, V., Ramachandan Nair, C.G.
Format: Article
Language:English
Subjects:
Chloramines
Hydrazines
Hydrogen-Ion Concentration
Isoniazid - analysis
Oxidation-Reduction
Phenylhydrazines
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Summary:Back-titration procedures with chloramine-T as the oxidant in 2 N acidic medium are described for the following compounds: hydrazine, phenylhydrazine, 2,4-dinitrophenylhydrazine, semicarbazide, p-nitrobenzhydrazide and isoniazid. In all cases, the oxidation, with consumption of 4 moles of chloramine-T per mole of sample, is quantitative in 15 min at room temperature. On décrit des procédés de titrage en retour à l'aide de chloramine-T comme oxydant, en milieu acide 2 N pour les composés suivants : hydrazine, phénylhydrazine, dinitro-2,4-phénylhydrazine, semicarbazide, p-nitrobenzhydrazide et isoniazide. Dans chaque cas, l'oxydation avec consommation de 4 moles de chloramine-T par mole d'échantillon, est quantitative en 15 min à la température ordinaire. Es werden Rücktitrationsverfahren mit Chloramin-T als Oxidationsmittel in 2 N säurem Medium für die Bestimmung folgender Verbindungen beschrieben : Hydrazin, Phenylhydrazin, 2,4-Dinitrophenylhydrazin, Semicarbazid, p-Nitro-benzhydrazid und Isoniazid. In allen Fällen ist die Oxidation, die unter Verbrauch von 4 Mol Chloramin-T pro Mol Probe verläuft, bei Raumtemperatur innerhalb 15 min quantitativ.
ISSN:0003-2670
1873-4324
DOI:10.1016/S0003-2670(01)95132-3