Analgesics: Synthesis of 1-Dioxolanoalkylnormeperidines and 1-Dioxanoalkylnormeperidines

The syntheses of the maleate salts of N-(2-methylene-1,3-dioxolano)normeperidine (II), N-(2-methylene-1,3-dioxano)normeperidine (III), N-(2-ethylene-1,3-dioxolano)normeperidine (IV), and N-(2-ethylene-1,3-dioxano)normeperidine (V) are reported. The dioxolane derivatives (II and IV) possessed analges...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1971-08, Vol.60 (8), p.1250-1251
Main Authors: Kriesel, Douglas C., Gisvold, Ole
Format: Article
Language:English
Subjects:
1-dioxanoalkylnormeperidines
1-Dioxanoalkylnormeperidines-synthesis as possible analgesics
1-Dioxolanoalkylnormeperidines-synthesis as possible analgesics
Analgesics
Analgesics - chemical synthesis
Analgesics, potential—synthesis, pharmacological evaluation of 1-dioxolanoalkylnormeperidines, 1-dioxanoalkylnormeperidines
Animals
Dioxins - chemical synthesis
Dioxoles - chemical synthesis
Female
Male
Meperidine - chemical synthesis
Mice
pharmacological evaluation of 1-dioxolanoalkylnormeperidines
potential-synthesis
Rats
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Summary:The syntheses of the maleate salts of N-(2-methylene-1,3-dioxolano)normeperidine (II), N-(2-methylene-1,3-dioxano)normeperidine (III), N-(2-ethylene-1,3-dioxolano)normeperidine (IV), and N-(2-ethylene-1,3-dioxano)normeperidine (V) are reported. The dioxolane derivatives (II and IV) possessed analgesic activity, with II being slightly more active than meperidine. None of these compounds antagonized the analgesic effect of meperidine.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600600833