Growth hormone- secreting pituitary adenomas: from molecular basis to treatment options in acromegaly

Acromegaly is a disease of exaggerated somatic growth and distorted proportion arising from hypersecretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). Although almost never malignant, somatotropinomas may cause significant morbidity and the uncontrolled excess of GH is related t...

Full description

Saved in:
Bibliographic Details
Published in:Cancer biology & therapy 2010-04, Vol.9 (7), p.483-492
Main Authors: Sabino, Simone Magnavita, Miranda, Paulo Augusto Carvalho, Ribeiro-Oliveira, Antonio
Format: Article
Language:English
Subjects:
Acromegaly - therapy
Adenoma - genetics
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Growth Hormone-Secreting Pituitary Adenoma - genetics
Humans
Landes
Organogenesis
Proteins
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Acromegaly is a disease of exaggerated somatic growth and distorted proportion arising from hypersecretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). Although almost never malignant, somatotropinomas may cause significant morbidity and the uncontrolled excess of GH is related to mortality 2 to 4 times higher than the expected rate. Recently, clinicians treating acromegalic patients have been aware of the importance of trying to normalize IGF-1 while GH values may differ depending on assay. Despite the significant efforts made over the last decade, little is known about the genetic causes of somatotropinomas and even less of this knowledge is applied therapeutically. In this review, we attempt to address the genetic and molecular knowledge regarding somatotropinomas and their therapeutic aspects.
ISSN:1538-4047
1555-8576
DOI:10.4161/cbt.9.7.11581