Bone morphogenetic protein-2 levels are elevated in the patients with gastric cancer and correlate with disease progression

• Published in: Medical oncology (Northwood, London, England) London, England), 2010-12, Vol.27 (4), p.1192-1199
• Main Authors: Park, Yong, Kang, Myoung Hee, Seo, Hee Yeon, Park, Joong Min, Choi, Chul Won, Kim, Yeul Hong, Kim, In Sun, Kim, Jun Suk, Oh, Sang Cheul
• Format: Article
• Language: English
• Subjects: Adenocarcinoma, Papillary - metabolism; Adenocarcinoma, Papillary - pathology; Adenocarcinoma, Papillary - surgery; Biomarkers, Tumor - metabolism; Blood; Bone morphogenetic protein 2; Bone Morphogenetic Protein 2 - metabolism; Carcinoma, Signet Ring Cell - metabolism; Carcinoma, Signet Ring Cell - pathology; Carcinoma, Signet Ring Cell - surgery; Case-Control Studies; Cell migration; Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; Gastrectomy; Gastric cancer; Gastric mucosa; Gastric Mucosa - metabolism; Gastric Mucosa - pathology; Hematology; Humans; Immunoenzyme Techniques; Internal Medicine; Lymph; Lymph Node Excision; Lymph nodes; Lymphatic Metastasis; Male; Medicine; Medicine & Public Health; Metastases; Middle Aged; Neoplasm Staging; Oncology; Original Paper; Pathology; Prognosis; Serum levels; Stains; Standard deviation; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; Survival Rate; Tissue Array Analysis; Tumors
• ISSN: 1357-0560; 1559-131X
• DOI: 10.1007/s12032-009-9358-x

Bone morphogenetic protein-2 (BMP-2) was reported to enhance migration, invasion, and metastasis at the various types of cancer cells. The purpose of this study is to identify the role of BMP-2 in progression of gastric cancer. Forty-four patients with operable gastric cancer were enrolled. Also, twenty healthy volunteers were enrolled as control group. All patients received gastrectomy with D2 lymphadenectomy, and surgical staging was performed. Whole blood was obtained preoperatively in all patients, and serum BMP-2 levels were quantified by commercially available ELISA kit. Immunohistochemical stain for BMP-2 in all gastric cancer tissues was performed using tissue microarray. All patients showed increased serum BMP-2 levels compared with control group, when upper normal limit was defined as the mean of control serum level + 2 × standard deviation. The mean serum BMP-2 level of lymph node positive group was significantly elevated than that of lymph node-negative group (382.7 pg/ml, 95% CI 341.99–423.4 pg/ml vs 211.69 pg/ml, 95% CI 191.09–232.29 pg/ml, P