2-Azetidinone – A new profile of various pharmacological activities

2-Azetidinone, a β-lactam four member heterocyclic compound involved in research aimed to evaluate new products that possess interesting biological activities. These compounds reported for their antimicrobial and antifungal activities. Successful introduction of aztreonam as a potent inhibitor of ce...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2010-12, Vol.45 (12), p.5541-5560
Main Authors: Mehta, Parul D., Sengar, N.P.S., Pathak, A.K.
Format: Article
Language:English
Subjects:
2-Azetidinone
Animals
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Antiparkinson Agents - chemistry
Antiparkinson Agents - pharmacology
Azetidines - chemistry
Azetidines - pharmacology
Biological activity
Biological and medical sciences
Four membered heterocyclic ring
Humans
Hypoglycemic Agents - chemistry
Hypoglycemic Agents - pharmacology
Medical sciences
Miscellaneous
Pharmacology. Drug treatments
β-Lactam
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Summary:2-Azetidinone, a β-lactam four member heterocyclic compound involved in research aimed to evaluate new products that possess interesting biological activities. These compounds reported for their antimicrobial and antifungal activities. Successful introduction of aztreonam as a potent inhibitor of cephalosporinase and ezetimibe as a cholesterol absorption inhibitor proved potential of 2-azetidinone moiety. Subsequently 2-azetidinones were highlighted as a potent mechanism based inhibitor of several enzymes like human tryptase, chymase, thrombin, leukocyte elastase, human cytomegalovirus protease and serine protease enzyme. These derivatives also known to possess antitubercular, anti-inflammatory, antitumor, anti-HIV, antiparkinsonian, antidiabetic and vasopressin V1a antagonist activity. The present review article focuses on the pharmacological profile of 2-azetidinones with their potential activities. 2-Azetidinone and their derivatives occupy a central place in medicinal chemistry due to their diverse and broad pharmacological profile. This article focuses on the various pharmacological profile of 2-azetidinone scaffold and development of novel derivatives with their potential activity. [Display omitted]
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2010.09.035