Tired legs—a gut diagnosis

A gluten-free diet was introduced with folic acid, oral vita min E, and parenteral vitamin B supplementation. Dorsal column demyelination is common in vitamin B12 deficiency; however, at autopsy both demyelination and inflammatory cell infiltration of dorsal columns have been reported in patients wi...

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Bibliographic Details
Published in:The Lancet (British edition) 2010-11, Vol.376 (9754), p.1798-1798
Main Authors: Di Lazzaro, Vincenzo, Dr, Pilato, Fabio, MD, Batocchi, Anna Paola, MD, Restuccia, Domenico, MD, Cammarota, Giovanni, MD, Profice, Paolo, MD
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Celiac disease
Celiac Disease - complications
Celiac Disease - diagnosis
Celiac Disease - diet therapy
Disease
Evoked Potentials, Somatosensory
Fatigue - etiology
Folic acid
General aspects
Gluten
Humans
Internal Medicine
Leg
Legs
Male
Medical sciences
Muscle Cramp - etiology
Neurophysiology
Spinal Cord Diseases - etiology
Vitamin B
Vitamin deficiency
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Summary:A gluten-free diet was introduced with folic acid, oral vita min E, and parenteral vitamin B supplementation. Dorsal column demyelination is common in vitamin B12 deficiency; however, at autopsy both demyelination and inflammatory cell infiltration of dorsal columns have been reported in patients with ataxia and gluten sensitivity, suggesting that immune mechanisms might also cause spinal cord damage.5 Physicians should consider coeliac disease as a cause of unexplained neurological abnormalities, even in older patients.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(10)61163-4