Relationship between left ventricular stimulation characteristics at implantation and echocardiographic response after 6 months of cardiac resynchronization therapy

Although the electrical stimulation of an ischaemic tissue adversely affects the left ventricular (LV) systolic function, the optimal stimulation site in patients with non-ischaemic cardiomyopathy has not been systematically studied. We hypothesized that the local stimulation characteristics at the...

Full description

Saved in:
Bibliographic Details
Published in:Europace (London, England) England), 2010-12, Vol.12 (12), p.1757-1761
Main Authors: Deplagne, Antoine, Ploux, Sylvain, Ritter, Philippe, Lafitte, Stephane, Reant, Patricia, Jais, Pierre, Haissaguerre, Michel, Clementy, Jacques, Bordachar, Pierre
Format: Article
Language:English
Subjects:
Aged
Cardiac Resynchronization Therapy
Cardiac Resynchronization Therapy Devices
Cardiomyopathies - physiopathology
Cardiomyopathies - therapy
Echocardiography
Female
Follow-Up Studies
Heart Ventricles - diagnostic imaging
Heart Ventricles - pathology
Heart Ventricles - physiopathology
Humans
Male
Middle Aged
Prospective Studies
Regression Analysis
Retrospective Studies
ROC Curve
Stroke Volume - physiology
Time Factors
Treatment Outcome
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Although the electrical stimulation of an ischaemic tissue adversely affects the left ventricular (LV) systolic function, the optimal stimulation site in patients with non-ischaemic cardiomyopathy has not been systematically studied. We hypothesized that the local stimulation characteristics at the time of device implantation predict the response to cardiac resynchronization therapy (CRT). We measured the impedance, sensing, and capture threshold of a bipolar LV lead in 138 patients with non-ischaemic cardiomyopathy undergoing first implantation of CRT device for drug refractory heart failure. All patients underwent echocardiography at baseline and at 6 months post-implantation. An absence of favourable response to CRT was defined as
ISSN:1099-5129
1532-2092
DOI:10.1093/europace/euq301