Late-Onset Intestinal Perforation in the Setting of Posttransplantation Microangiopathy: A Case Report

Abstract Intestinal perforation in the setting of posttransplantation microangiopathy (TMA) is a very rare event and might be considered a terminal event of intestinal microangiopathy (i-TMA), a rather rarely recognized posttransplantation complication, as it overlaps with the more common intestinal...

Full description

Saved in:
Bibliographic Details
Published in:Transplantation proceedings 2010-11, Vol.42 (9), p.3892-3893
Main Authors: Aljitawi, O.S, Rodriguez, L, Madan, R, Ganguly, S, Abhyankar, S, McGuirk, J.P
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal, Murine-Derived - therapeutic use
Biological and medical sciences
Colectomy
Fatal Outcome
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunologic Factors - therapeutic use
Intestinal Perforation - etiology
Intestinal Perforation - pathology
Intestinal Perforation - therapy
Intestines - transplantation
Ischemia - etiology
Ischemia - pathology
Ischemia - therapy
Medical sciences
Middle Aged
Organ Transplantation - adverse effects
Other diseases. Semiology
Plasmapheresis
Rituximab
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Thrombotic Microangiopathies - etiology
Thrombotic Microangiopathies - pathology
Thrombotic Microangiopathies - therapy
Time Factors
Tissue, organ and graft immunology
Transplantation, Homologous
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Intestinal perforation in the setting of posttransplantation microangiopathy (TMA) is a very rare event and might be considered a terminal event of intestinal microangiopathy (i-TMA), a rather rarely recognized posttransplantation complication, as it overlaps with the more common intestinal graft-versus-host disease (GVHD). Cases of i-TMA described in literature occurred within with first 100 days posttransplantation or shortly thereafter. In this report, we describe a case of late-onset intestinal perforation that occurred in the setting of systemic microangiopathy more than a year after allogeneic transplantation. In our case, the patient poorly responded to treatment secondary to refractory mircoangiopathy.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2010.08.025