Aerosolized Tacrolimus: A Case Report in a Lung Transplant Recipient

Abstract Long-term outcomes after lung transplantation remain poor mainly to the development of bronchiolitis obliterans syndrome (BOS). Currently, treatment options for BOS are very limited. Strategies to prevent and treat this complication include the use of aerosolized therapy with only cyclospor...

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Bibliographic Details
Published in:Transplantation proceedings 2010-11, Vol.42 (9), p.3876-3879
Main Authors: Hayes, D., Jr, Zwischenberger, J.B, Mansour, H.M
Format: Article
Language:English
Subjects:
Administration, Inhalation
Adult
Aerosols
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Bronchiolitis Obliterans - drug therapy
Bronchiolitis Obliterans - etiology
Bronchiolitis Obliterans - physiopathology
Dyspnea - drug therapy
Dyspnea - etiology
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunosuppressive Agents - administration & dosage
Lung Transplantation - adverse effects
Medical sciences
Nebulizers and Vaporizers
Pharmacology. Drug treatments
Respiratory Function Tests
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tacrolimus - administration & dosage
Time Factors
Tissue, organ and graft immunology
Treatment Outcome
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Summary:Abstract Long-term outcomes after lung transplantation remain poor mainly to the development of bronchiolitis obliterans syndrome (BOS). Currently, treatment options for BOS are very limited. Strategies to prevent and treat this complication include the use of aerosolized therapy with only cyclosporine used in patients to date. We describe the use of aerosolized tacrolimus in a lung transplant recipient with BOS. The patient demonstrated clinical improvement in functional capacity and oxygenation while receiving tacrolimus by nebulization. Further research is needed to study whether aerosolized tacrolimus is beneficial in lung transplant recipients with BOS.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2010.08.029