Regulation of Rat Liver Glucose 6-Phosphate Dehydrogenase Levels by Adenosine 3',5'-Monophosphate

Glucagon and cyclic adenosine 3',5'-monophosphate (cyclic AMP) have been shown to prevent the induction of rat liver glucose-6-P dehydrogenase which normally occurs when fasted rats are fed a high carbohydrate, non-fat diet. This is a specific effect which can occur without any change in t...

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Bibliographic Details
Published in:The Journal of biological chemistry 1971-12, Vol.246 (24), p.7823-7824
Main Authors: Rudack, D, Davie, B, Holten, D
Format: Article
Language:English
Subjects:
Animals
Butyrates - pharmacology
Cyclic AMP - pharmacology
Dietary Carbohydrates - pharmacology
Dietary Fats
Enzyme Induction
Enzyme Repression
Glucosephosphate Dehydrogenase - biosynthesis
Liver - drug effects
Liver - enzymology
Rats
Theophylline - pharmacology
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Summary:Glucagon and cyclic adenosine 3',5'-monophosphate (cyclic AMP) have been shown to prevent the induction of rat liver glucose-6-P dehydrogenase which normally occurs when fasted rats are fed a high carbohydrate, non-fat diet. This is a specific effect which can occur without any change in the amount of diet consumed. It is concluded that increases in the level of cyclic AMP may repress the synthesis of lipogenic enzymes as well as induce the synthesis of several gluconeogenic enzymes. Thus, the regulation of carbohydrate and lipid metabolism mediated by cyclic AMP may be exerted at the level of enzyme synthesis as well as by more rapid processes involving the activation and inactivation of enzymes.
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(19)45851-1