Secretory IgA responses in rats to antigens of various developmental stages of Nippostrongylus brasiliensis

Intestinal and faecal IgA responses against different developmental stages of Nippostrongylus brasiliensis were studied in Hooded Lister rats vaccinated subcutaneously with infective larvae or intragastrically with 4th-stage larvae, adult nematodes, adult worm somatic and metabolic antigens. It was...

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Bibliographic Details
Published in:Parasitology 1984-08, Vol.89 (1), p.145-158
Main Authors: Wedrychowicz, H., Maclean, J. M., Holmes, P. H.
Format: Article
Language:English
Subjects:
Animals
antigens
Antigens - immunology
Antigens, Surface - immunology
Biological and medical sciences
developmental stages
Experimental helminthic diseases. Models
Feces - immunology
Female
Helminthic diseases
Immunization
Immunoglobulin A, Secretory - biosynthesis
immunoglobulins
Infectious diseases
Intestinal Diseases, Parasitic - immunology
Intestinal Mucosa - immunology
local immunity
Medical sciences
Nematode Infections - immunology
Nippostrongylus - growth & development
Nippostrongylus - immunology
Nippostrongylus brasiliensis
Parasitic diseases
Rats
secretory component
vaccination
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Summary:Intestinal and faecal IgA responses against different developmental stages of Nippostrongylus brasiliensis were studied in Hooded Lister rats vaccinated subcutaneously with infective larvae or intragastrically with 4th-stage larvae, adult nematodes, adult worm somatic and metabolic antigens. It was found that intragastric administration of L4 or adult worms produced as high resistance to challenge as normal infection. Oral vaccination with adult nematode excretory–secretory (ES) and somatic antigens produced 69 and 17% protection respectively. All vaccination regimes induced a considerable IgA response against somatic and metabolic antigens of the intestinal stages. However, no correlation could be seen between the IgA levels and degree of protection. Analysis of intestinal mucosal, intestinal contents and faecal IgA specific to larval or adult antigens suggests that the IgA is probably induced by antigen(s) common to all intestinal stages. Also secretory IgA responses against surface antigens of intestinal L4 did not show stage specificity, although this was detected in sera.
ISSN:0031-1820
1469-8161
DOI:10.1017/S0031182000001190