Alzheimer's Disease: Cell-Specific Pathology Isolates the Hippocampal Formation

Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex. The affected cells are precisely those that interconnect the hippocampal formation with the as...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1984-09, Vol.225 (4667), p.1168-1170
Main Authors: Hyman, Bradley T., Van Hoesen, Gary W., Damasio, Antonio R., Barnes, Clifford L.
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - pathology
Alzheimer's disease
Alzheimers disease
Biological and medical sciences
Brain
Brain research
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Entorhinal cortex
Forebrain
Hippocampus
Hippocampus (Brain)
Hippocampus - pathology
Humans
Medical sciences
Memory
Middle Aged
Nervous system diseases
Neurofibrillary tangles
Neurology
Neurons
Neurons - pathology
Neuroscience
Pathology
Physiological aspects
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Summary:Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex. The affected cells are precisely those that interconnect the hippocampal formation with the association cortices, basal forebrain, thalamus, and hypothalamus, structures crucial to memory. This focal pattern of pathology isolates the hippocampal formation from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6474172