Specific Olfactory Receptor Populations Projecting to Identified Glomeruli in the Rat Olfactory Bulb

A critical gap exists in our knowledge of the topographical relationship between the olfactory epithelium and olfactory bulb. The present report describes the application to this problem of a method involving horseradish peroxidase conjugated to wheat germ agglutinin. This material was iontophoretic...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1984-08, Vol.81 (16), p.5250-5254
Main Authors: Jastreboff, P. J., Pedersen, P. E., Greer, C. A., Stewart, W. B., Kauer, J. S., Benson, T. E., Shepherd, G. M.
Format: Article
Language:English
Subjects:
Animals
Axonal Transport
Dendrites
Epithelium
Horseradish Peroxidase
Injection sites
Lectins
Neurons
Nose
Odors
Olfactory bulb
Olfactory Bulb - anatomy & histology
Olfactory Bulb - physiology
Olfactory Pathways - anatomy & histology
Olfactory receptors
Rats
Rats, Inbred Strains
Receptors
Sensory Receptor Cells - anatomy & histology
Sensory Receptor Cells - physiology
Suckling
Wheat Germ Agglutinins
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Summary:A critical gap exists in our knowledge of the topographical relationship between the olfactory epithelium and olfactory bulb. The present report describes the application to this problem of a method involving horseradish peroxidase conjugated to wheat germ agglutinin. This material was iontophoretically delivered to circumscribed glomeruli in the olfactory bulb and the characteristics and distribution of retrogradely labeled receptor cells were assessed. After discrete injections into small glomerular groups in the caudomedial bulb, topographically defined populations of receptor cells were labeled. Labeled receptor cell somata appeared at several levels within the epithelium. The receptor cell apical dendrites followed a tight helical course towards the surface of the epithelium. The data thus far demonstrate that functional units within the olfactory system may include not only glomeruli as previously suggested but, in addition, a corresponding matrix of receptor cells possessing functional and topographical specificity.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.81.16.5250