Scintigraphy of Normal Mouse Ovaries with Monoclonal Antibodies to ZP-2, the Major Zona Pellucida Protein

The zona pellucida is an extracellular glycocalyx, made of three sulfated glycoproteins, that surrounds mammalian oocytes. Parenterally administered monoclonal antibodies specific for ZP-2, the most abundant zona protein, localize in the zona pellucida. When labeled with iodine-125, these monoclonal...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1984-08, Vol.225 (4665), p.938-941
Main Authors: East, Iain J., Keenan, Andrew M., Larson, Steven M., Dean, Jurrien
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibodies, Monoclonal - analysis
Antigens
Cancer
Cancer research
Digestive System - immunology
Egg Proteins
Female
Glycoproteins - analysis
Glycoproteins - immunology
Iodine Radioisotopes
Liver
Liver - immunology
Male
Medical radiography
Membrane Glycoproteins
Mice
Monoclonal antibodies
Myocardium - immunology
Nuclear medicine
Oncology, Experimental
Oocytes
Ovaries
Ovary - analysis
Ovary - diagnostic imaging
Ovary - immunology
Ovum - analysis
Radioactive decay
Radiography, Medical
Radionuclide Imaging
Receptors, Cell Surface
Tissue Distribution
Tumors
Zona pellucida
Zona Pellucida - analysis
Zona Pellucida - immunology
Zona Pellucida Glycoproteins
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Summary:The zona pellucida is an extracellular glycocalyx, made of three sulfated glycoproteins, that surrounds mammalian oocytes. Parenterally administered monoclonal antibodies specific for ZP-2, the most abundant zona protein, localize in the zona pellucida. When labeled with iodine-125, these monoclonal antibodies demonstrate a remarkably high target-to-nontarget tissue ratio and provide clear external radioimaging of ovarian tissue.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6474160