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DNA Markers for Nervous System Diseases
Recombinant DNA technology has provided a vast new source of DNA markers displaying heritable sequence variation in humans. These markers can be used in family studies to identify the chromosomal location of defective genes causing nervous system disorders. The discovery of a DNA marker linked to Hu...
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| Published in: | Science (American Association for the Advancement of Science) 1984-09, Vol.225 (4668), p.1320-1326 |
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| Main Authors: | , , , , , , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c414t-f1876bab2d4acdad9d05d7e132c344573595a62358e2bbc9eaddfbbc03c80d653 |
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| cites | cdi_FETCH-LOGICAL-c414t-f1876bab2d4acdad9d05d7e132c344573595a62358e2bbc9eaddfbbc03c80d653 |
| container_end_page | 1326 |
| container_issue | 4668 |
| container_start_page | 1320 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 225 |
| creator | Gusella, James F. Tanzi, Rudolph E. Anderson, Mary Anne Hobbs, Wendy Gibbons, Kerin Raschtchian, Roya Gilliam, T. Conrad Wallace, Margaret R. Wexler, Nancy S. Conneally, P. Michael |
| description | Recombinant DNA technology has provided a vast new source of DNA markers displaying heritable sequence variation in humans. These markers can be used in family studies to identify the chromosomal location of defective genes causing nervous system disorders. The discovery of a DNA marker linked to Huntington's disease has opened new avenues of research into this disorder and may ultimately permit cloning and characterization of the defective gene. |
| doi_str_mv | 10.1126/science.6089346 |
| format | article |
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Conrad ; Wallace, Margaret R. ; Wexler, Nancy S. ; Conneally, P. Michael</creator><creatorcontrib>Gusella, James F. ; Tanzi, Rudolph E. ; Anderson, Mary Anne ; Hobbs, Wendy ; Gibbons, Kerin ; Raschtchian, Roya ; Gilliam, T. Conrad ; Wallace, Margaret R. ; Wexler, Nancy S. ; Conneally, P. Michael</creatorcontrib><description>Recombinant DNA technology has provided a vast new source of DNA markers displaying heritable sequence variation in humans. These markers can be used in family studies to identify the chromosomal location of defective genes causing nervous system disorders. The discovery of a DNA marker linked to Huntington's disease has opened new avenues of research into this disorder and may ultimately permit cloning and characterization of the defective gene.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.6089346</identifier><identifier>PMID: 6089346</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Alleles ; Base Sequence ; Biological and medical sciences ; Chromosome Mapping ; Chromosomes ; Cloning, Molecular ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; DNA ; DNA - genetics ; DNA Restriction Enzymes ; DNA, Recombinant ; Female ; Genes ; Genetic diseases ; Genetic Linkage ; Genetic loci ; Genetic Markers ; Genetic mutation ; Genetic Vectors ; Haplotypes ; Humans ; Huntington disease ; Huntington Disease - genetics ; Male ; Medical genetics ; Medical sciences ; Mutation ; Neurology ; Neurosciences ; Pedigree ; Phenotype ; Polymorphism, Genetic</subject><ispartof>Science (American Association for the Advancement of Science), 1984-09, Vol.225 (4668), p.1320-1326</ispartof><rights>Copyright 1984 The American Association for the Advancement of Science</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-f1876bab2d4acdad9d05d7e132c344573595a62358e2bbc9eaddfbbc03c80d653</citedby><cites>FETCH-LOGICAL-c414t-f1876bab2d4acdad9d05d7e132c344573595a62358e2bbc9eaddfbbc03c80d653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2884,2885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9015729$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6089346$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gusella, James F.</creatorcontrib><creatorcontrib>Tanzi, Rudolph E.</creatorcontrib><creatorcontrib>Anderson, Mary Anne</creatorcontrib><creatorcontrib>Hobbs, Wendy</creatorcontrib><creatorcontrib>Gibbons, Kerin</creatorcontrib><creatorcontrib>Raschtchian, Roya</creatorcontrib><creatorcontrib>Gilliam, T. Conrad</creatorcontrib><creatorcontrib>Wallace, Margaret R.</creatorcontrib><creatorcontrib>Wexler, Nancy S.</creatorcontrib><creatorcontrib>Conneally, P. Michael</creatorcontrib><title>DNA Markers for Nervous System Diseases</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Recombinant DNA technology has provided a vast new source of DNA markers displaying heritable sequence variation in humans. These markers can be used in family studies to identify the chromosomal location of defective genes causing nervous system disorders. The discovery of a DNA marker linked to Huntington's disease has opened new avenues of research into this disorder and may ultimately permit cloning and characterization of the defective gene.</description><subject>Alleles</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Chromosome Mapping</subject><subject>Chromosomes</subject><subject>Cloning, Molecular</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>DNA</subject><subject>DNA - genetics</subject><subject>DNA Restriction Enzymes</subject><subject>DNA, Recombinant</subject><subject>Female</subject><subject>Genes</subject><subject>Genetic diseases</subject><subject>Genetic Linkage</subject><subject>Genetic loci</subject><subject>Genetic Markers</subject><subject>Genetic mutation</subject><subject>Genetic Vectors</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Huntington disease</subject><subject>Huntington Disease - genetics</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Mutation</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Pedigree</subject><subject>Phenotype</subject><subject>Polymorphism, Genetic</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><recordid>eNpFkM1PwzAMxSMEGmNw5gJSDwhO3fLRpMlx2viSxjgA5ypNXKmjXUfcIe2_p2jVdrKl9_Oz_Qi5ZnTMGFcTdCWsHYwV1UYk6oQMGTUyNpyKUzKkVKhY01SekwvEFaWdZsSADHp8SB7my2n0ZsM3BIyKJkRLCL_NFqOPHbZQR_MSwSLgJTkrbIVw1dcR-Xp6_Jy9xIv359fZdBG7hCVtXDCdqtzm3CfWeeuNp9KnwAR3IklkKqSRVnEhNfA8dwas90XXUOE09UqKEbnf-25C87MFbLO6RAdVZdfQnZVpxkWSSt2Bkz3oQoMYoMg2oaxt2GWMZv_RZH00Wf9rN3HbW2_zGvyBP-p3vW7R2aoIdu1KPGCGMply02E3e2yFbROOW5URymjxB_IedbA</recordid><startdate>19840921</startdate><enddate>19840921</enddate><creator>Gusella, James F.</creator><creator>Tanzi, Rudolph E.</creator><creator>Anderson, Mary Anne</creator><creator>Hobbs, Wendy</creator><creator>Gibbons, Kerin</creator><creator>Raschtchian, Roya</creator><creator>Gilliam, T. Conrad</creator><creator>Wallace, Margaret R.</creator><creator>Wexler, Nancy S.</creator><creator>Conneally, P. Michael</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840921</creationdate><title>DNA Markers for Nervous System Diseases</title><author>Gusella, James F. ; Tanzi, Rudolph E. ; Anderson, Mary Anne ; Hobbs, Wendy ; Gibbons, Kerin ; Raschtchian, Roya ; Gilliam, T. Conrad ; Wallace, Margaret R. ; Wexler, Nancy S. ; Conneally, P. Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-f1876bab2d4acdad9d05d7e132c344573595a62358e2bbc9eaddfbbc03c80d653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Alleles</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Chromosome Mapping</topic><topic>Chromosomes</topic><topic>Cloning, Molecular</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>DNA</topic><topic>DNA - genetics</topic><topic>DNA Restriction Enzymes</topic><topic>DNA, Recombinant</topic><topic>Female</topic><topic>Genes</topic><topic>Genetic diseases</topic><topic>Genetic Linkage</topic><topic>Genetic loci</topic><topic>Genetic Markers</topic><topic>Genetic mutation</topic><topic>Genetic Vectors</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Huntington disease</topic><topic>Huntington Disease - genetics</topic><topic>Male</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Mutation</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Pedigree</topic><topic>Phenotype</topic><topic>Polymorphism, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gusella, James F.</creatorcontrib><creatorcontrib>Tanzi, Rudolph E.</creatorcontrib><creatorcontrib>Anderson, Mary Anne</creatorcontrib><creatorcontrib>Hobbs, Wendy</creatorcontrib><creatorcontrib>Gibbons, Kerin</creatorcontrib><creatorcontrib>Raschtchian, Roya</creatorcontrib><creatorcontrib>Gilliam, T. 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Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DNA Markers for Nervous System Diseases</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1984-09-21</date><risdate>1984</risdate><volume>225</volume><issue>4668</issue><spage>1320</spage><epage>1326</epage><pages>1320-1326</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Recombinant DNA technology has provided a vast new source of DNA markers displaying heritable sequence variation in humans. These markers can be used in family studies to identify the chromosomal location of defective genes causing nervous system disorders. The discovery of a DNA marker linked to Huntington's disease has opened new avenues of research into this disorder and may ultimately permit cloning and characterization of the defective gene.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>6089346</pmid><doi>10.1126/science.6089346</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1984-09, Vol.225 (4668), p.1320-1326 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81234758 |
| source | American Association for the Advancement of Science |
| subjects | Alleles Base Sequence Biological and medical sciences Chromosome Mapping Chromosomes Cloning, Molecular Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DNA DNA - genetics DNA Restriction Enzymes DNA, Recombinant Female Genes Genetic diseases Genetic Linkage Genetic loci Genetic Markers Genetic mutation Genetic Vectors Haplotypes Humans Huntington disease Huntington Disease - genetics Male Medical genetics Medical sciences Mutation Neurology Neurosciences Pedigree Phenotype Polymorphism, Genetic |
| title | DNA Markers for Nervous System Diseases |
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