Improved detection of focal lesions with computerized tomographic examination of the liver using ethiodized oil emulsion (EOE‐13) liver contrast

A prospective study of computerized tomography (CT) of the liver using a liver contrast agent compared to conventional CT was undertaken. CT scanning without contrast agents (NC‐CT), CT with water‐soluble contrast (WSC‐CT), and CT with ethiodized oil emulsion (EOE‐CT) were performed on patients with...

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Bibliographic Details
Published in:Cancer 1984-10, Vol.54 (8), p.1489-1495
Main Authors: Sugarbaker, Paul H., Vermess, Michael, Doppman, John L., Miller, Donald L., Simon, Richard
Format: Article
Language:English
Subjects:
Biological and medical sciences
Ethiodized Oil
Evaluation Studies as Topic
False Positive Reactions
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Liver - diagnostic imaging
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - secondary
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Prospective Studies
Tomography, X-Ray Computed - methods
Tumors
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Summary:A prospective study of computerized tomography (CT) of the liver using a liver contrast agent compared to conventional CT was undertaken. CT scanning without contrast agents (NC‐CT), CT with water‐soluble contrast (WSC‐CT), and CT with ethiodized oil emulsion (EOE‐CT) were performed on patients with possible or probable hepatic metastases. The findings on these three examinations were compared to the objective findings at surgery in 53 patients. Accuracy of these examinations was 80.7% for NC‐CT, 77.1% for WSC‐CT, and 84.9% for EOE‐CT. The true‐positive percentage for 129 hepatic lesions was 40.6% for the NC‐CT, 33.6% for WSC‐CT, and 76.7% for the EOE‐CT. Eighty‐three percent (44/53) of 1‐ to 2‐cm liver lesions were detected by EOE‐CT, whereas only 26.4% (14/53) lesions of this size were detected by the NC‐CT and 20.4% (10/49) shown by WSC‐CT. The likelihood that a lesion seen by CT scan was malignant was 84.6% for NC‐CT, 89.4% for WSC‐CT, and 81.8% for EOE‐CT. The EOE contrast agent improves the sensitivity of liver CT for detecting hepatic metastases. The improvement occurs with lesions 1 cm and greater in diameter, but is particularly striking for lesions of 1 to 2 cm in diameter.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19841015)54:8<1489::AID-CNCR2820540802>3.0.CO;2-#