Accentuated negative inotropism of verapamil after ischaemic intervention in isolated working rat heart

We examined the effects of a clinically relevant concentration (2×10−7 mol·litre−1) of verapamil on the cardiac functions of isolated working rat hearts during global ischaemia (15 min) and reperfusion (30 min). The aorta and the left atrium of each heart of male Sprague-Dawley rats were cannulated...

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Bibliographic Details
Published in:Cardiovascular research 1984-10, Vol.18 (10), p.639-644
Main Authors: KONISHI, TAKASHI, NAKAMURA, YASUYUKI, KONISHI, TOMOTSUGU, KAWAI, CHUICHI
Format: Article
Language:English
Subjects:
Animals
Antianginal agents. Coronary vasodilator agents
Biological and medical sciences
Blood Pressure - drug effects
Cardiovascular system
Coronary Disease - enzymology
Coronary Disease - physiopathology
Creatine Kinase - metabolism
Depression, Chemical
In Vitro Techniques
isolated working rat heart
Male
Medical sciences
Myocardial Contraction - drug effects
myocardial ischaemia
negative inotropic effect
Perfusion
Pharmacology. Drug treatments
Rats
Rats, Inbred Strains
verapamil
Verapamil - pharmacology
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Summary:We examined the effects of a clinically relevant concentration (2×10−7 mol·litre−1) of verapamil on the cardiac functions of isolated working rat hearts during global ischaemia (15 min) and reperfusion (30 min). The aorta and the left atrium of each heart of male Sprague-Dawley rats were cannulated for perfusion with Krebs-Henseleit solution, and a soft elastic catheter was introduced into the left ventricle through the left atrial cannula. Verapamil slightly increased the left ventricular end-diastolic pressure, and slightly decreased the left ventricular dP/dt, but did not reduce the left ventricular peak systolic pressure before ischaemia. During the early phase of ischaemia and reperfusion, verapamil (n=6) lowered the left ventricular peak systolic pressure and the left ventricular dP/dt in comparison with the controls (n=6) (left ventricular peak systolic pressure 45.4± 16.9 versus 60.9±15.2 mmHg: p
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/18.10.639