Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

We have purified the human T-cell growth factor (interleukin-2) receptor and have cloned, sequenced and expressed cDNAs corresponding to this receptor. We identify one gene, but two interleukin-2 receptor mRNAs which differ in their polyadenylation signals. We have isolated an additional cDNA that m...

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Bibliographic Details
Published in:Nature (London) 1984-10, Vol.311 (5987), p.626-631
Main Authors: Leonard, Warren J, Depper, Joel M, Crabtree, Gerald R, Rudikoff, Stuart, Pumphrey, Janet, Robb, Richard J, Krönke, Martin, Svetlik, Penny B, Peffer, Nancy J, Waldmann, Thomas A, Greene, Warner C
Format: Article
Language:English
Subjects:
AIDS/HIV
Amino Acid Sequence
Analysis of the immune response. Humoral and cellular immunity
Base Sequence
Biological and medical sciences
Cell interactions
Cloning, Molecular
Deltaretrovirus - genetics
DNA - metabolism
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genes
Genes, Viral
Humanities and Social Sciences
Humans
Immunobiology
multidisciplinary
Nucleic Acid Hybridization
Protein Biosynthesis
Receptors, Antigen, T-Cell - genetics
Receptors, Immunologic - genetics
Receptors, Immunologic - isolation & purification
Receptors, Interleukin-2
RNA, Messenger - genetics
Science
Science (multidisciplinary)
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Summary:We have purified the human T-cell growth factor (interleukin-2) receptor and have cloned, sequenced and expressed cDNAs corresponding to this receptor. We identify one gene, but two interleukin-2 receptor mRNAs which differ in their polyadenylation signals. We have isolated an additional cDNA that may correspond to an alternatively spliced mRNA that lacks a 216 base segment and appears to encode an altered membrane protein which cannot bind interleukin-2.
ISSN:0028-0836
1476-4687
DOI:10.1038/311626a0