Imaging of Soft Tissue Tumors with Tc(V)-99m Dimercaptosuccinic Acid: A New Tumor-seeking Agent

• Published in: Clinical nuclear medicine 1984-10, Vol.9 (10), p.568-569
• Main Authors: OHTA, HITOYA, ENDO, KEIGO, FUJITA, TORU, NAKAJIMA, TETSUO, SAKAHARA, HARUMI, TORIZUKA, KANJI, SHIMIZU, YASUTOMO, HATA, NAOTAKA, MASUDA, HIDESUKE, HORIUCHI, KAZUKO, YOKOYAMA, AKIRA, IKEKUBO, KATSUJI, INOUE, NORIHIKO, TAMURA, KIYOSHI, KOTOURA, YOSHIHIKO, ISHII, MASAO, YOSHIZUMI, MASAYUKI
• Format: Article
• Language: English
• Subjects: Abscess - diagnostic imaging; Adult; Aged; False Negative Reactions; False Positive Reactions; Female; Fibroma - diagnostic imaging; Gallium Radioisotopes; Histiocytoma, Benign Fibrous - diagnostic imaging; Humans; Lipoma - diagnostic imaging; Male; Middle Aged; Neurilemmoma - diagnostic imaging; Neuroectodermal Tumors, Primitive, Peripheral - diagnostic imaging; Radionuclide Imaging; Soft Tissue Neoplasms - diagnostic imaging; Succimer; Sulfhydryl Compounds; Synovitis - diagnostic imaging; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid
• ISSN: 0363-9762; 1536-0229
• DOI: 10.1097/00003072-198410000-00007

Tumor scintigraphy, using Tc(V)-99m dimercaptosuccinic acid (Tc(V)-DMS) was performed in 58 patients with soft tissue tumors, and the results were compared with that of Ga-67 citrate. Tc(V)-DMS was found to have a sensitivity of 90% for malignant tumors including aggressive fibromatosis compared to that of Ga-67 citrate, which was 56%. However, the specificity of Tc(V)-DMS for these tumors was 71% but with Ga-67 citrate the specificity was 80%. The imaging accuracy in soft tissue tumors with Tc(V)-DMS and Ga-67 citrate was 78% and 71%, respectively. Although the accumulation of Tc(V)-DMS has been detected in some benign soft tissue tumors, the reduced accumulation in inflammatory lesions compared to Ga-67 citrate was recognized, and Tc(V)-DMS could be of great use in the detection of extension or location of malignant soft tissue tumors.