Pharmacokinetics of Pentobarbital, Quinidine, Lidocaine, and Theophylline in the Thermally Injured Rat

Previous studies have shown that rats with 15% third-degree burns show a severe depression in various in vitro hepatic drug-metabolizing enzymes. This effect was assessed in vivo by measuring the disposition of four liver-metabolized drugs in 16% third-degree burned rats at 7 d postburn. Compared wi...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pharmaceutical sciences 1984-08, Vol.73 (8), p.1117-1121
Main Authors: Fruncillox, Richard J., John Digregorio, G.
Format: Article
Language:English
Subjects:
and theophylline
Animals
Biological and medical sciences
Burns - metabolism
Dialysis
General pharmacology
Kinetics
lidocaine
Lidocaine - blood
Lidocaine - metabolism
Lidocaine-pharmacokinetics in thermally injured rats
Male
Medical sciences
Pentobarbital - blood
Pentobarbital - metabolism
Pentobarbital-pharmacokinetics in thermally injured rats
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
quindine
Quinidine - blood
Quinidine - metabolism
Quinidine-pharmacokinetics in thermally injured rats
Rats
Rats, Inbred Strains
Theophylline - blood
Theophylline - metabolism
Theophylline-pharmacokinetics in thermally injured rats
Thermal injury-phramacokinetics of pentobarbital
Thermal injury—phramacokinetics of pentobarbital, quindine, lidocaine, and theophylline, rats
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Previous studies have shown that rats with 15% third-degree burns show a severe depression in various in vitro hepatic drug-metabolizing enzymes. This effect was assessed in vivo by measuring the disposition of four liver-metabolized drugs in 16% third-degree burned rats at 7 d postburn. Compared with pair-fed control rats, pentobarbital demonstrated a significantly prolonged clearance and elimination half-life without a change in volume of distribution. Quinidine demonstrated a significantly increased volume of distribution and a significantly decreased clearance without a change in elimination half-life. Lidocaine showed a significantly increased volume of distribution. Theophylline, which is only 50% metabolized in the rat, showed no changes in any pharmacokinetic parameters. The free drug fractions of quinidine and lidocaine were found to be significantly decreased at 1 d postburn and normal at 7 d postburn. These results warrant pharmacokinetic studies in human burn patients.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600730823