Insulin and apolipoprotein A-1/C-III gene polymorphisms relating to hypertriglyceridaemia and diabetes mellitus

Two gene specific probes have been used to identify polymorphic DNA loci on chromosome 11 close to the insulin and apoprotein A-1 genes in a genetic analysis of hypertriglyceridaemic patients with and without co-existing diabetes. Of the 45 patients studied with both probes, 15 were diabetic of whom...

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Bibliographic Details
Published in:Diabetologia 1984-08, Vol.27 (2), p.180-183
Main Authors: JOWETT, N. I, REES, A, STOCKS, J, VELLA, M. A, HITMAN, G. A, KATZ, J, GALTON, D. J
Format: Article
Language:English
Subjects:
Adult
Aged
Apolipoprotein A-I
Apolipoprotein C-III
Apolipoproteins A - genetics
Apolipoproteins C - genetics
Associated diseases and complications
Biological and medical sciences
Diabetes Mellitus - genetics
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Female
Humans
Insulin - genetics
Male
Medical sciences
Middle Aged
Polymorphism, Genetic
Triglycerides - blood
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Summary:Two gene specific probes have been used to identify polymorphic DNA loci on chromosome 11 close to the insulin and apoprotein A-1 genes in a genetic analysis of hypertriglyceridaemic patients with and without co-existing diabetes. Of the 45 patients studied with both probes, 15 were diabetic of whom nine possessed class 3/3 insulin polymorphism genotypes, compared with none in the non-diabetic group (p less than 0.001; chi 2 test). In contrast, an uncommon apolipoprotein A-1 polymorphism was found to be equally distributed in the diabetic and the non-diabetic patients. No co-segregation of these two particular genetic polymorphisms was found in either patient group. The differing associations of the two disease-related polymorphism genotypes in patients with hypertriglyceridaemia with or without co-existing diabetes may possibly reflect differing aetiologies of the hyperlipidaemia.
ISSN:0012-186X
1432-0428
DOI:10.1007/BF00273802