Evidence for a role of the cytoskeleton in the in vitro folliculogenesis of the thyroid gland of the fetal rat

Thyrotropic hormone (TSH) or cAMP accelerate the formation of follicular cavities in the explanted thyroid gland of the 15-day-old rat fetus. Cytochalasin B or vinblastine and nocodazole or colchicine, which disorganize microfilamental and microtubular structures respectively, inhibit or completely...

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Bibliographic Details
Published in:Cell and tissue research 1984-08, Vol.237 (3), p.499-508
Main Authors: PIC, P, REMY, L, ATHOUEL-HAON, A.-M, MAZZELLA, E
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cyclic AMP - pharmacology
Cytochalasin B - pharmacology
Cytoskeleton - ultrastructure
Dimethyl Sulfoxide - pharmacology
Embryology: invertebrates and vertebrates. Teratology
Female
Fetus
Fundamental and applied biological sciences. Psychology
Lumicolchicines - pharmacology
Microscopy, Electron
Organ Culture Techniques
Organogenesis. Fetal development
Organogenesis. Physiological fonctions
Pregnancy
Rats
Rats, Inbred Strains
Thyroid Gland - drug effects
Thyroid Gland - embryology
Thyroid Gland - ultrastructure
Thyrotropin - pharmacology
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Summary:Thyrotropic hormone (TSH) or cAMP accelerate the formation of follicular cavities in the explanted thyroid gland of the 15-day-old rat fetus. Cytochalasin B or vinblastine and nocodazole or colchicine, which disorganize microfilamental and microtubular structures respectively, inhibit or completely block in vitro-induced folliculogenesis. Exposure of the thyroid tissue to lumicolchicine, a structural isomer of colchicine deprived of antimicrotubular activity, does not inhibit the activation of folliculogenesis induced by TSH. These results are strong evidence for the supposition that microfilaments and microtubules are involved in the TSH-stimulated mechanisms resulting in thyroid folliculogenesis. Folliculogenesis requires the integrity of both microfilaments and microtubules.
ISSN:0302-766X
1432-0878
DOI:10.1007/BF00228434