Altered Enzymes in Ageing Human Fibroblasts

Diploid human fibroblasts accumulate heat labile enzymes during the final stages of their life-span in culture. The RNA base analogue 5-FU induces premature senescence, which is preceded by the appearance of altered enzyme. These observations support Orgel's “error catastrophe” theory of ageing...

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Bibliographic Details
Published in:Nature (London) 1972-07, Vol.238 (5358), p.26-30
Main Authors: HOLLIDAY, R, TARRANT, G. M
Format: Article
Language:English
Subjects:
Cell Death
Cell Line
Cellular Senescence - drug effects
Enzyme Stability
Fibroblasts - cytology
Fibroblasts - drug effects
Fibroblasts - enzymology
Fibroblasts - physiology
Fluorouracil - pharmacology
Glucosephosphate Dehydrogenase - metabolism
Hot Temperature
Humanities and Social Sciences
Humans
Male
multidisciplinary
Phosphogluconate Dehydrogenase - metabolism
Science
Science (multidisciplinary)
Substrate Specificity
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Description
Summary:Diploid human fibroblasts accumulate heat labile enzymes during the final stages of their life-span in culture. The RNA base analogue 5-FU induces premature senescence, which is preceded by the appearance of altered enzyme. These observations support Orgel's “error catastrophe” theory of ageing.
ISSN:0028-0836
1476-4687
DOI:10.1038/238026a0