In Vivo Bronchoalveolar Macrophage Defense Against Rhizopus oryzae and Aspergillus fumigatus

The ability of bronchoalveolar macrophages from normal, diabetic, and cortisone-treated mice to inhibit spore germination and kill fungal spores in vivo was investigated. The data indicated that the normal host controls different fungal infections in the lungs by different mechanisms. Prevention of...

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Bibliographic Details
Published in:The Journal of infectious diseases 1984-11, Vol.150 (5), p.752-760
Main Authors: Waldorf, Alayn R., Levitz, Stuart M., Diamond, Richard D.
Format: Article
Language:English
Subjects:
Animals
Aspergillosis - complications
Aspergillosis - immunology
Aspergillosis - microbiology
Aspergillus fumigatus - immunology
Aspergillus fumigatus - physiology
Biological and medical sciences
Bronchi
Conidia
Cortisone - analogs & derivatives
Cortisone - therapeutic use
Diabetes
Diabetes complications
Diabetes Mellitus, Experimental - complications
Diabetes Mellitus, Experimental - immunology
Experimental mycoses and models
Female
Fungal spores
Germination
Infectious diseases
Lung - microbiology
Lung Diseases, Fungal - complications
Lung Diseases, Fungal - immunology
Lung Diseases, Fungal - microbiology
Lungs
Macrophages
Macrophages - immunology
Medical sciences
Mice
Mucormycosis - complications
Mucormycosis - immunology
Mucormycosis - microbiology
Mycoses
Phagocytosis
Pulmonary Alveoli
Rhizopus - immunology
Rhizopus - physiology
Spore germination
Spores, Fungal - immunology
Spores, Fungal - physiology
Therapeutic irrigation
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Description
Summary:The ability of bronchoalveolar macrophages from normal, diabetic, and cortisone-treated mice to inhibit spore germination and kill fungal spores in vivo was investigated. The data indicated that the normal host controls different fungal infections in the lungs by different mechanisms. Prevention of mucormycosis required inhibition of fungal spore germination by alveolar macrophages. In contrast, pulmonary defense against aspergillosis depended on early killing of conidia by alveolar macrophages and not on inhibition of germination by bronchoalveolar macrophages. Bronchoalveolar macrophages in diabetic and cortisone-treated animals allowed fungal spore germination, thereby permitting infection by Rhizopus oryzae. In the cortisone-treated mouse, bronchoalveolar macrophages did not kill fungal conidia and progressive infection by Asperigillus fumigatus occurred. Fungicidal activity of bronchoalveolar macrophages was measured with a new in vivo killing assay.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/150.5.752