Induction, Course, and Transmissibility of Monkeypox in the Baboon (Papio cynocephalus)

All of six baboons (Papio cynocephalus) inoculated intramuscularly with monkeypox virus became infected and one died. Two of six sentinel animals also became infected through natural transmission of the virus from infected roommates. Clinical symptoms observed included the formation of vesicular les...

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Bibliographic Details
Published in:The Journal of infectious diseases 1971-07, Vol.124 (1), p.33-38
Main Authors: Heberling, R. L., Kalter, S. S.
Format: Article
Language:English
Subjects:
Animal diseases
Animals
Animals, Laboratory
Antibodies
Antibody Formation
Complement Fixation Tests
Epidemiology
Haplorhini
Hemagglutination Inhibition Tests
Hemolytic Plaque Technique
Infections
Inoculation
Lesions
Monkey Diseases - immunology
Monkey Diseases - microbiology
Original Articles
Papio
Poxviridae
Poxviridae Infections - immunology
Poxviridae Infections - veterinary
Primates
Sentinel animals
Viruses
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Description
Summary:All of six baboons (Papio cynocephalus) inoculated intramuscularly with monkeypox virus became infected and one died. Two of six sentinel animals also became infected through natural transmission of the virus from infected roommates. Clinical symptoms observed included the formation of vesicular lesions on the extremities, face, lips, and buccal cavity approximately eight days after infection. At the same time HAI and plaque-neutralizing (PN) antibodies were detected. One week later CF antibody was formed. Peak titers of antibody were reached within one week after they were first detected. With the exception of PN antibodies, a gradual decline to a plateau was noted over a 16-week period. Immunity after natural infection was demonstrated by failure of animals to develop disease when they were given a challenge inoculation of monkeypox virus intramuscularly. The results suggest that it would be advisable to immunize colonies of primates in captivity against monkeypox.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/124.1.33