Conversion-Associated Recombination in Yeast

Gene conversion and conversion-associated reciprocal recombination have been studied in various Saccharomyces cerevisiae hybrids. In a sample of 11,023 unselected meiotic tetrads, 907 conversions were observed at the arg4, thr3, his1, and SUP6 loci. Of these conversions, 445 (or 49.1%) were associat...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1972-01, Vol.69 (1), p.101-105
Main Authors: Hurst, Donald D., Fogel, Seymour, Mortimer, Robert K.
Format: Article
Language:English
Subjects:
Alleles
Binding Sites
Biological Sciences: Genetics
Chromosomes
Crossing Over, Genetic
Crossovers
Diploidy
DNA
Gene conversion
Genes
Genetic loci
Genotype
Hybrid Cells
Hybridity
Medical genetics
Meiosis
Recombination, Genetic
Saccharomyces
Saccharomyces cerevisiae
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Summary:Gene conversion and conversion-associated reciprocal recombination have been studied in various Saccharomyces cerevisiae hybrids. In a sample of 11,023 unselected meiotic tetrads, 907 conversions were observed at the arg4, thr3, his1, and SUP6 loci. Of these conversions, 445 (or 49.1%) were associated with reciprocal recombination of bracketing markers no more than 20-centimorgans apart. For conversions of two other loci, his2 and thr1, for which the bracketing markers were more than 20-centimorgans apart, recombination frequencies were significantly greater than 50%. These findings are discussed in terms of current models of genetic recombination. It is suggested that all meiotic crossing-over is characterized by the recombination events that are associated with conversion.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.69.1.101