Growth Inhibitor from BSC-1 Cells Closely Related to Platelet Type β Transforming Growth Factor

Purified growth inhibitor from BSC-1 cells and type β transforming growth factor from human platelets are shown to have nearly identical biological activity and to compete for binding to the same cell membrane receptor. These findings suggest that the growth inhibitor and the type β transforming gro...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1984-11, Vol.226 (4675), p.705-707
Main Authors: Tucker, Ronald F., Shipley, Gary D., Moses, Harold L., Holley, Robert W.
Format: Article
Language:English
Subjects:
3T3 cells
Active sites (Biochemistry)
Animals
Binding sites (Biochemistry)
Biological and medical sciences
Blood platelets
Cell growth
Cell lines
Cell Membrane - metabolism
Cell membranes
Cell physiology
Cercopithecus aethiops
Cultured cells
DNA - biosynthesis
Epithelial cells
Fundamental and applied biological sciences. Psychology
Growth inhibitors
Growth Inhibitors - isolation & purification
Growth Inhibitors - metabolism
Growth Inhibitors - pharmacology
Kidney cells
Molecular and cellular biology
Peptides - metabolism
Peptides - pharmacology
Plant growth inhibiting substances
Platelets
Receptors
Receptors, Cell Surface - metabolism
Responses to growth factors, tumor promotors, other factors
Transforming Growth Factors
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Summary:Purified growth inhibitor from BSC-1 cells and type β transforming growth factor from human platelets are shown to have nearly identical biological activity and to compete for binding to the same cell membrane receptor. These findings suggest that the growth inhibitor and the type β transforming growth factor are similar molecules. The data also show that the same purified polypeptide can either stimulate or inhibit cell proliferation depending on the experimental conditions.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6093254