Stimulation of the Sodium Pump in the Red Blood Cell by Lithium and Potassium

THE efflux of the 22 Na at 37° C from normal human red blood cells incubated with 22 Na into media containing different concentrations of potassium and lithium has been studied. Lithium at concentrations of 3 mM and 6 mM causes a significant stimulation of efflux, when the concentration of potassium...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 1972-10, Vol.239 (5372), p.399-401
Main Authors: GLEN, A. I. M, BRADBURY, M. W. B, WILSON, JANET
Format: Article
Language:English
Subjects:
Dose-Response Relationship, Drug
Enzyme Activation - drug effects
Erythrocytes - drug effects
Erythrocytes - enzymology
Erythrocytes - metabolism
Humanities and Social Sciences
Humans
Ion Transport - drug effects
Kinetics
letter
Lithium - pharmacology
multidisciplinary
Potassium - pharmacology
Science
Science (multidisciplinary)
Sodium-Potassium-Exchanging ATPase - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:THE efflux of the 22 Na at 37° C from normal human red blood cells incubated with 22 Na into media containing different concentrations of potassium and lithium has been studied. Lithium at concentrations of 3 mM and 6 mM causes a significant stimulation of efflux, when the concentration of potassium is zero or 2 mM, but the effect of lithium is not apparent in the presence of 6 mM potassium which itself causes a big stimulation. This stimulation of the sodium pump by extracellular lithium may explain observations of a low intracellular sodium concentration under such conditions. It may be relevant to the prophylactic action of lithium salts in manic-depressive disease.
ISSN:0028-0836
1476-4687
DOI:10.1038/239399a0