Shiga-Like Toxin-Converting Phages from Escherichia coli Strains that Cause Hemorrhagic Colitis or Infantile Diarrhea

Escherichia coli K-12 acquired the ability to produce a high titer of Shiga-like toxin after lysogenization by either of two different bacteriophages isolated from a highly toxinogenic Escherichia coli 0157:H7 strain that causes hemorrhagic colitis. One of these phages and another Shiga-like toxin-c...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1984-11, Vol.226 (4675), p.694-696
Main Authors: O'Brien, Alison D., Newland, John W., Miller, Steven F., Holmes, Randall K., Smith, H. Williams, Formal, Samuel B.
Format: Article
Language:English
Subjects:
Animals
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Bacterial Toxins - metabolism
Bacteriophages
Bacteriophages - metabolism
Biological and medical sciences
Colitis
Colitis, Ulcerative - microbiology
Diarrhea
Diarrhea, Infantile - microbiology
DNA
DNA, Viral - metabolism
Escherichia coli
Escherichia coli - metabolism
Gels
Human bacterial diseases
Humans
Infantile diarrhea
Infectious diseases
Medical sciences
Rabbits
Shiga Toxins
Shigella dysenteriae
Toxins
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Summary:Escherichia coli K-12 acquired the ability to produce a high titer of Shiga-like toxin after lysogenization by either of two different bacteriophages isolated from a highly toxinogenic Escherichia coli 0157:H7 strain that causes hemorrhagic colitis. One of these phages and another Shiga-like toxin-converting phage from an Escherichia coli 026 isolate associated with infantile diarrhea were closely related in terms of morphology, virion polypeptides, DNA restriction fragments, lysogenic immunity, and heat stability, although a difference in host range was noted. These phages are currently the best-characterized representatives from a broader family of Shiga-like toxin-converting phages.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6387911