Multiple Alpha Chain Loci for Human Haemoglobins: Hb J-Buda and Hb G-Pest

IT is well established that at least two independent loci control the structure of human haemoglobin A 1,2 . Although the primary structure of the β-chain is determined by a single genetic locus, there are conflicting reports that the α-chain is controlled by one 3 or two 4,5 loci. We now describe g...

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Bibliographic Details
Published in:Nature (London) 1972-01, Vol.235 (5332), p.47-50
Main Authors: HOLLÁN, S. R, SZELENYI, J. G, BRIMHALL, B, DUERST, M, JONES, R. T, KOLER, R. D, STOCKLEN, Z
Format: Article
Language:English
Subjects:
Alleles
Blood Protein Electrophoresis
Chromatography, DEAE-Cellulose
Chromosome Mapping
Electrophoresis
Female
Genes
Genotype
Hemoglobinopathies - genetics
Hemoglobins, Abnormal - analysis
Humanities and Social Sciences
Humans
letter
Male
Middle Aged
multidisciplinary
Pedigree
Science
Science (multidisciplinary)
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Summary:IT is well established that at least two independent loci control the structure of human haemoglobin A 1,2 . Although the primary structure of the β-chain is determined by a single genetic locus, there are conflicting reports that the α-chain is controlled by one 3 or two 4,5 loci. We now describe genetic and chemical studies of a Budapest family which possess two abnormal α-chain haemoglobins, Hb J-Buda and Hb G-Pest, and review evidence for multiple loci for the α-chain.
ISSN:0028-0836
1476-4687
DOI:10.1038/235047a0