Cell Aggregation: Role of Acid Mucopolysaccharides

Factors that induce cell aggregation are released by several types of chick embryo and mammalian cell cultures. These aggregation factors are also present in some serums. The factors in each of the preparations tested were inactivated by treatment with bovine testicular hyaluronidase. Conversely, hy...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1972-02, Vol.175 (4024), p.898-900
Main Authors: Pessac, Bernard, Defendi, Vittorio
Format: Article
Language:English
Subjects:
Aggregation
Animals
Cell aggregates
Cell Aggregation - drug effects
Cell culture techniques
Cell Line
Cell lines
Cells
Cells, Cultured - analysis
Chick Embryo
Chromatography
Cricetinae
Cultured cells
Epithelioid cells
Glycosaminoglycans - antagonists & inhibitors
Glycosaminoglycans - isolation & purification
Glycosaminoglycans - pharmacology
Humans
Hyaluronic Acid - analysis
Hyaluronic Acid - pharmacology
Hyaluronoglucosaminidase - pharmacology
Liver cells
Mice
Neoplasms, Experimental
Neurons
Rats
Ungulates
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Summary:Factors that induce cell aggregation are released by several types of chick embryo and mammalian cell cultures. These aggregation factors are also present in some serums. The factors in each of the preparations tested were inactivated by treatment with bovine testicular hyaluronidase. Conversely, hyaluronic acid promoted aggregation of only those cells that were aggregated by media containing the factors. These factors appear to be acid mucopolysaccharides, with hyaluronic acid being a major component.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.175.4024.898