Cimetidine-induced alterations in desipramine plasma concentrations

Concurrent administration of cimetidine for 4 days to eight patients taking maintenance doses of desipramine led to significant elevations of desipramine (P less than 0.001) and its hydroxylated metabolite 2-hydroxydesipramine (P less than 0.001). The mean increase in desipramine plasma levels was 5...

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Bibliographic Details
Published in:Psychopharmacologia 1984-01, Vol.83 (4), p.373-375
Main Authors: AMSTERDAM, J. D, BRUNSWICK, D. J, POTTER, L, KAPLAN, M. J
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biotransformation
Cimetidine - pharmacology
Desipramine - analogs & derivatives
Desipramine - blood
Desipramine - therapeutic use
Humans
Medical sciences
Middle Aged
Neuropharmacology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
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Summary:Concurrent administration of cimetidine for 4 days to eight patients taking maintenance doses of desipramine led to significant elevations of desipramine (P less than 0.001) and its hydroxylated metabolite 2-hydroxydesipramine (P less than 0.001). The mean increase in desipramine plasma levels was 51% and that for 2-hydroxydesipramine was 46%. The present results suggest that tricyclic antidepressant plasma level monitoring might be indicated for certain patients taking concurrent cimetidine and desipramine.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00428548