THE MAIN HISTOCOMPATIBILITY COMPLEX AND AGEING IN MICE AND MEN

Studies of the relationship between the main histocompatibility complex and survival into old age are reviewed. In mice there is some evidence that the H2 system is involved with longevity. Studies in very old humans may help to explain the survival of genes modulating different immune responsivenes...

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Bibliographic Details
Published in:Age and ageing 1984-09, Vol.13 (5), p.291-294
Main Author: Kafetz, K
Format: Article
Language:English
Subjects:
Ageing, cell death
Aging
Animals
Biological and medical sciences
Cell physiology
Female
Fundamental and applied biological sciences. Psychology
H-2 Antigens - immunology
Histocompatibility Antigens Class II - immunology
HLA Antigens - immunology
HLA-B8 Antigen
HLA-DR3 Antigen
Humans
Immune System - immunology
Major Histocompatibility Complex
Male
Mice - immunology
Molecular and cellular biology
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Summary:Studies of the relationship between the main histocompatibility complex and survival into old age are reviewed. In mice there is some evidence that the H2 system is involved with longevity. Studies in very old humans may help to explain the survival of genes modulating different immune responsiveness.
ISSN:0002-0729
1468-2834
DOI:10.1093/ageing/13.5.291