Heterogeneous growth and mental development of intrauterine growth-retarded infants during the first 3 years of life

Postnatal growth and development were studied in two groups of term infants with intrauterine growth retardation (IUGR) and one group of infants with normal birth weight up to 3 years of age (total sample, 205 infants). Infants with IUGR were classified as having low ponderal index (IUGR-LPI) or ade...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1984-11, Vol.74 (5), p.783-791
Main Authors: VILLAR, J, SMERIGLIO, V, MARTORELL, R, BROWN, C. H, KLEIN, R. E
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Body Height
Body Weight
Cephalometry
Child Development
Child, Preschool
Emergency and intensive care: neonates and children. Prematurity. Sudden death
Female
Fetal Growth Retardation - physiopathology
Follow-Up Studies
Growth
Humans
Infant
Infant, Newborn
Intensive care medicine
Medical sciences
Pregnancy
Prognosis
Time Factors
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Summary:Postnatal growth and development were studied in two groups of term infants with intrauterine growth retardation (IUGR) and one group of infants with normal birth weight up to 3 years of age (total sample, 205 infants). Infants with IUGR were classified as having low ponderal index (IUGR-LPI) or adequate ponderal index (IUGR-API). At birth, the two groups of infants with IUGR had similar birth weight, but length and head circumference measurements were significantly different. Overall, the IUGR-API infants remained lighter and shorter and had smaller head circumferences up to 30 months of age. The IUGR-LPI infants experienced catch-up growth in weight during the first months, because of greater fat deposition. At 24 months of age, the IUGR-API infants scored below the others on mental items. At 3 years of age the IUGR-API infants had the lowest values on seven of eight developmental measures and on the composite score; at these two time periods, the group with normal birth weight scored the highest, and the IUGR-LPI infants obtained intermediate values. It is concluded that infants with IUGR tend to follow postnatal growth and developmental patterns that are associated with their physical characteristics at birth.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.74.5.783