Transfer of age-associated restrained tumor growth in mice by old-to-young bone marrow transplantation

B16 melanoma and Lewis lung carcinoma grow more slowly in aged mice. Immunesenescent changes may account for this age-related difference. To test for the effect of immune deficiency on the growth of these tumors, we treated young mice with an immunosuppressive dose of radiation and then observed tum...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1984-12, Vol.44 (12), p.5677-5680
Main Authors: ERSHLER, W. B, MOORE, A. L, SHORE, H, GAMELLI, R. L
Format: Article
Language:English
Subjects:
Aging
Animals
Biological and medical sciences
Bone Marrow - growth & development
Bone Marrow Transplantation
Cell Division
Host-tumor relations. Immunology. Biological markers
Immune Tolerance - radiation effects
Immunosuppression
Lung Neoplasms - pathology
Lung Neoplasms - secondary
Medical sciences
Melanoma - pathology
Mice
Mice, Inbred C57BL
Tumors
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Summary:B16 melanoma and Lewis lung carcinoma grow more slowly in aged mice. Immunesenescent changes may account for this age-related difference. To test for the effect of immune deficiency on the growth of these tumors, we treated young mice with an immunosuppressive dose of radiation and then observed tumor growth. We also radiated young mice to a higher (lethal) dose and then rescued them with either young or old bone marrow transfusion. Tumors grew more slowly in radiated mice than controls and in those reconstituted with old bone marrow. These findings support the concept of immunesenescent-related reduced tumor growth.
ISSN:0008-5472
1538-7445