LYSINOMICIN, A NEW AMINOGLYCOSIDE ANTIBIOTIC: II. STRUCTURE AND STEREOCHEMISTRY

The structure of lysinomicin, a new aminocyclitol antibiotic, was established as 3-epi -2'-N-(L-β-lysyl)-4', 5'-didehydro-6'-de-C-methylfortimicin B (1) on the basis of spectral evidence and chemical degradation of the antibiotic. In the course of the degradation of 1, three addi...

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Bibliographic Details
Published in:Journal of antibiotics 1984, Vol.37(10), pp.1130-1143
Main Authors: KURATH, PAUL, ROSENBROOK, WILLIAM, DUNNIGAN, DANIEL A., MCALPINE, JAMES B., EGAN, RICHARD S., STANASZEK, RUTH S., CIROVIC, MOMIR, MUELLER, SANDRA L., WASHBURN, WILLIAM H.
Format: Article
Language:English
Subjects:
Aminoglycosides
Anti-Bacterial Agents
Biological and medical sciences
Chemical Phenomena
Chemistry
General pharmacology
Medical sciences
Molecular Conformation
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
Spectrum Analysis
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Summary:The structure of lysinomicin, a new aminocyclitol antibiotic, was established as 3-epi -2'-N-(L-β-lysyl)-4', 5'-didehydro-6'-de-C-methylfortimicin B (1) on the basis of spectral evidence and chemical degradation of the antibiotic. In the course of the degradation of 1, three additional compounds with interesting biological properties were obtained: 3-epi-2'-N-(L-β-lysyl)-6'-de-C-methylfortimicin B (4), 3-epi-4', 5'-didehydro-6'-de-C-methylfortimicin B (6) and 3-epi-6'-de-C-methylfortimicin B (7).
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.37.1130