LYSINOMICIN, A NEW AMINOGLYCOSIDE ANTIBIOTIC: II. STRUCTURE AND STEREOCHEMISTRY

The structure of lysinomicin, a new aminocyclitol antibiotic, was established as 3-epi -2'-N-(L-β-lysyl)-4', 5'-didehydro-6'-de-C-methylfortimicin B (1) on the basis of spectral evidence and chemical degradation of the antibiotic. In the course of the degradation of 1, three addi...

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Published in:Journal of antibiotics 1984, Vol.37(10), pp.1130-1143
Main Authors: KURATH, PAUL, ROSENBROOK, WILLIAM, DUNNIGAN, DANIEL A., MCALPINE, JAMES B., EGAN, RICHARD S., STANASZEK, RUTH S., CIROVIC, MOMIR, MUELLER, SANDRA L., WASHBURN, WILLIAM H.
Format: Article
Language:English
Subjects:
Aminoglycosides
Anti-Bacterial Agents
Biological and medical sciences
Chemical Phenomena
Chemistry
General pharmacology
Medical sciences
Molecular Conformation
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
Spectrum Analysis
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container_end_page 1143
container_issue 10
container_start_page 1130
container_title Journal of antibiotics
container_volume 37
creator KURATH, PAUL
ROSENBROOK, WILLIAM
DUNNIGAN, DANIEL A.
MCALPINE, JAMES B.
EGAN, RICHARD S.
STANASZEK, RUTH S.
CIROVIC, MOMIR
MUELLER, SANDRA L.
WASHBURN, WILLIAM H.
description The structure of lysinomicin, a new aminocyclitol antibiotic, was established as 3-epi -2'-N-(L-β-lysyl)-4', 5'-didehydro-6'-de-C-methylfortimicin B (1) on the basis of spectral evidence and chemical degradation of the antibiotic. In the course of the degradation of 1, three additional compounds with interesting biological properties were obtained: 3-epi-2'-N-(L-β-lysyl)-6'-de-C-methylfortimicin B (4), 3-epi-4', 5'-didehydro-6'-de-C-methylfortimicin B (6) and 3-epi-6'-de-C-methylfortimicin B (7).
doi_str_mv 10.7164/antibiotics.37.1130
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source JSTAGE
subjects Aminoglycosides
Anti-Bacterial Agents
Biological and medical sciences
Chemical Phenomena
Chemistry
General pharmacology
Medical sciences
Molecular Conformation
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
Spectrum Analysis
title LYSINOMICIN, A NEW AMINOGLYCOSIDE ANTIBIOTIC: II. STRUCTURE AND STEREOCHEMISTRY
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