β-LACTAMASE INDUCTION BY N-FORMIMIDOYLTHIENAMYCIN

Clinical isolates were grown in the presence of subinhibitory concentrations of N-formimidoylthienamycin (NFT) in Mueller-Hinton broth in microtiter plates. beta -Lactamase activity was detected using nitrocefin according to the method described the NEU. beta -Lactamase induction was demonstrated in...

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Bibliographic Details
Published in:Journal of antibiotics 1984, Vol.37(9), pp.1101-1102
Main Authors: GRAPPEL, SARAH F., GIOVENELLA, ALBERT J., NEWMAN, DAVID J., NISBET, LOUIS J.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
beta-Lactamases - biosynthesis
Drug Resistance, Microbial
Enterobacter
Enzyme Induction
Imipenem
Morganella
Proteus
Providencia
Pseudomonas
Pseudomonas aeruginosa - enzymology
Serratia
Thienamycins - pharmacology
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Summary:Clinical isolates were grown in the presence of subinhibitory concentrations of N-formimidoylthienamycin (NFT) in Mueller-Hinton broth in microtiter plates. beta -Lactamase activity was detected using nitrocefin according to the method described the NEU. beta -Lactamase induction was demonstrated in 21/24 strains of Gram-negative bacteria tested, including strains of Enterobacter, Serratia, Pseudomas, Morganella, Provindencia and Proteus .
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.37.1101