Effect of Aramine on the Survival of Dogs Subjected to Hemorrhagic Hypotension

One group of 19 control dogs and other group of 20 “treated” dogs were bled into hemorrhagic hypotension after Nembutal anesthesia and their arterial pressures controlled at 40 mm. Hg for an average period of one hour and fifteen minutes. Neither group had further blood depletion, or replacement, fo...

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Bibliographic Details
Published in:Circulation research 1954-09, Vol.2 (5), p.420-423
Main Authors: Sarnoff, Stanley J, Kaufman, Herbert E
Format: Article
Language:English
Subjects:
Animals
Dogs
Hemorrhage
Hypotension
Metaraminol
Old Medline
Sympathomimetics
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Summary:One group of 19 control dogs and other group of 20 “treated” dogs were bled into hemorrhagic hypotension after Nembutal anesthesia and their arterial pressures controlled at 40 mm. Hg for an average period of one hour and fifteen minutes. Neither group had further blood depletion, or replacement, for an additional 1 hour and 39 minutes, but the treated group received Aramine. Reinfusion was performed after an oligemic period totaling 2 hours and 54 minutes. Of the dogs in the control group, 10.5 per cent survived; 50 per cent of the treated dogs survived.
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.2.5.420