Molecular Defect in a Gamma-2 (γ2) Heavy Chain

The first gamma-2 (γ2) heavy chain disease protein Gif has pyrrolidinecarboxylic acid as its amino terminal residue, much of the Fd variable region, and an internal deletion of the heavy chain of about 100 residues corresponding to most of the Fd constant region. Normal sequence resumes with a gluta...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1972-04, Vol.176 (4031), p.187-189
Main Authors: Cooper, Sheldon M., Franklin, Edward C., Frangione, Blas
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino acids
Amino Acids - blood
Autoradiography
Carbohydrates
Cholinergic receptors
Chromatography
Disulfides
Electrophoresis
End plates
gamma-Globulins - analysis
Heavy Chain Disease - blood
Humans
Molecular chains
Molecular Weight
Molecules
Myeloma Proteins - analysis
Peptides - blood
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Description
Summary:The first gamma-2 (γ2) heavy chain disease protein Gif has pyrrolidinecarboxylic acid as its amino terminal residue, much of the Fd variable region, and an internal deletion of the heavy chain of about 100 residues corresponding to most of the Fd constant region. Normal sequence resumes with a glutamic acid residue at position 216 in the hinge region. This is the third gamma heavy chain disease protein where normal sequence resumes at the same position after the deletion.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.176.4031.187