Antitumor Agents V: Cytotoxic Cardenolides from Cryptostegia grandiflora (Roxb.) R. Br

An alcoholic extract of the aboveground parts of Cryptostegia gradiflora showed inhibitory activity against the KB cell culture and was fractionated through a series of partitions and column chromatography to yield five cardenolides: oleandrigenin, 16‐propionylgitoxigenin—a new natural product, 16‐a...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1972-04, Vol.61 (4), p.570-573
Main Authors: Doskotch, Raymond W., Younas Malik, M., Hufford, Charles D., Malik, Shah N., Trent, John E., Kubelka, Wolfgang
Format: Article
Language:English
Subjects:
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - therapeutic use
Antitumor agents
Antitumor agents, potential—five cardenolides from Cryptostegia grandiflora
Carcinoma - drug therapy
Cardanolides - isolation & purification
Cardanolides - therapeutic use
Cardenolides-isolation from Cryptostegia grandiflora
Cardenolides—isolation from Cryptostegia grandiflora, identification, cytotoxic activity
Cardiac Glycosides - isolation & purification
Cardiac Glycosides - therapeutic use
Cell Line
Chromatography
Chromatography, Thin Layer
Cryptostegia grandiflora (Roxb.) R. Br.-isolation
Cryptostegia grandiflora (Roxb.) R. Br.—isolation, identification of five cytotoxic cardenolides
cytotoxic activity
Cytotoxicity-five cardenolides from Cryptostegia grandiflora
Humans
identification
identification of five cytotoxic cardenolides
Infrared Rays
Magnetic Resonance Spectroscopy
Mass Spectrometry
Mouth Neoplasms - drug therapy
plant biochemistry
Plant Extracts - analysis
plant physiology
Plants - analysis
potential-five cardenolides from Cryptostegia grandiflora
Spectrum Analysis
Ultraviolet Rays
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Summary:An alcoholic extract of the aboveground parts of Cryptostegia gradiflora showed inhibitory activity against the KB cell culture and was fractionated through a series of partitions and column chromatography to yield five cardenolides: oleandrigenin, 16‐propionylgitoxigenin—a new natural product, 16‐anhydrogitoxigenin, gitoxigenin, and rhodexin B.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600610415