Roles of fibroblast growth factor receptors in carcinogenesis

The fibroblast growth factor receptors (FGFR) play essential roles both during development and in the adult. Upon ligand binding, FGFRs induce intracellular signaling networks that tightly regulate key biological processes, such as cell proliferation, survival, migration, and differentiation. Deregu...

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Bibliographic Details
Published in:Molecular cancer research 2010-11, Vol.8 (11), p.1439-1452
Main Authors: Haugsten, Ellen Margrethe, Wiedlocha, Antoni, Olsnes, Sjur, Wesche, Jørgen
Format: Article
Language:English
Subjects:
Adult
Animals
Cell Transformation, Neoplastic - metabolism
Humans
Neoplasms - enzymology
Neoplasms - metabolism
Neoplasms - pathology
Receptor Protein-Tyrosine Kinases - metabolism
Receptors, Fibroblast Growth Factor - metabolism
Signal Transduction
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Summary:The fibroblast growth factor receptors (FGFR) play essential roles both during development and in the adult. Upon ligand binding, FGFRs induce intracellular signaling networks that tightly regulate key biological processes, such as cell proliferation, survival, migration, and differentiation. Deregulation of FGFR signaling can thus alter tissue homeostasis and has been associated with several developmental syndromes as well as with many types of cancer. In human cancer, FGFRs have been found to be deregulated by multiple mechanisms, including aberrant expression, mutations, chromosomal rearrangements, and amplifications. In this review, we will give an overview of the main FGFR alterations described in human cancer to date and discuss their contribution to cancer progression.
ISSN:1541-7786
1557-3125
DOI:10.1158/1541-7786.mcr-10-0168