Clinical Study of 28 Cases of Paediatric Idiopathic Pulmonary Haemosiderosis

Objective: To summarize the clinical characteristics of idiopathic pulmonary haemosiderosis (IPH) to explore the aetiopathogenesis, risk factors, diagnosis and experiences in therapy of IPH. Methods: The documents of 28 IPH cases, who were hospitalized in Children’s Hospital of Fudan University betw...

Full description

Saved in:
Bibliographic Details
Published in:Journal of tropical pediatrics (1980) 2010-12, Vol.56 (6), p.386-390
Main Authors: Zhang, Xiaobo, Wang, Libo, Lu, Aizhen, Zhang, Mingzhi
Format: Article
Language:English
Subjects:
Age of Onset
Anemia, Iron-Deficiency - complications
Biological and medical sciences
Bronchoalveolar Lavage Fluid
Bronchoscopy
Child
China
Female
General aspects
Glucocorticoids - therapeutic use
Hemoptysis - etiology
Hemosiderosis - diagnosis
Hemosiderosis - drug therapy
Hemosiderosis - etiology
Hemosiderosis - physiopathology
Hospitals, Pediatric
Hospitals, Teaching
Humans
Lung Diseases - complications
Lung Diseases - diagnosis
Lung Diseases - drug therapy
Lung Diseases - physiopathology
Male
Medical sciences
Prednisone - therapeutic use
Risk Factors
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: To summarize the clinical characteristics of idiopathic pulmonary haemosiderosis (IPH) to explore the aetiopathogenesis, risk factors, diagnosis and experiences in therapy of IPH. Methods: The documents of 28 IPH cases, who were hospitalized in Children’s Hospital of Fudan University between February 1989 and June 2009 were reviewed. Results: (i) fifteen cases were males and 13 were females, and 88.5% of the cases had first onset under the age of 10 years; (ii) the triad occurred in 57.1% cases; (iii) radiographic features of IPH including diffuse alveolar-type infiltrates, ground glass attenuation, interstitial reticular and micronodular patterns; (iv) haemosiderin-laden macrophages were found in 60.7% of the cases;(v) the trend of positive correlation was found between the severity of ventilatory restrictive pattern and the disease courses (r = 0.229, p = 0.237); and (vi) glucocorticosteroids can control the symptoms. Conclusion: (i) the clinical presentations are not classical. If long-term anaemia exists without reason, this case must be considered; (ii) corticosteroid can control the symptom; and (iii) IPH may be associated with the imbalance of immune system.
ISSN:0142-6338
1465-3664
DOI:10.1093/tropej/fmq010