Physiological Disposition of Fenoprofen in Man II: Plasma and Urine Pharmacokinetics after Oral and Intravenous Administration

• Published in: Journal of pharmaceutical sciences 1972-05, Vol.61 (5), p.739-745
• Main Authors: Rubin, Alan, Rodda, Bruce E., Warrick, Patricia, Ridolfo, Anthony S., Gruber, Charles M.
• Format: Article
• Language: English
• Subjects: 4′-Hydroxyfenoprofen glucuronide-major urinary metabolite of fenoprofen; 4′-Hydroxyfenoprofen glucuronide—major urinary metabolite of fenoprofen, man; Administration, Oral; Adult; Carbon Isotopes; dl-2-(3-Phenoxyphenyl)propionic acid-urinary and plasma kinetics compared after oral and intravenous administration; dl-2-(3-Phenoxyphenyl)propionic acid—urinary and plasma kinetics compared after oral and intravenous administration, major urinary metabolites identified, man; Ethers - administration & dosage; Ethers - blood; Ethers - metabolism; Ethers - urine; Fenoprofen glucuronide-major urinary metabolite of fenoprofen; Fenoprofen glucuronide—major urinary metabolite of fenoprofen, man; fenoprofen-compared to plasma kinetics; Fenoprofen-urinary and plasma kinetics compared after oral and intravenous administration; Fenoprofen—urinary and plasma kinetics compared after oral and intravenous administration, major urinary metabolites identified, man; Glucuronates - urine; Half-Life; Humans; Injections, Intravenous; Intestinal Absorption; Kinetics; major metabolites identified; major urinary metabolites identified; Male; man; Models, Biological; Propionates - administration & dosage; Propionates - blood; Propionates - metabolism; Propionates - urine; Time Factors; Urinary kinetics; Urinary kinetics, fenoprofen—compared to plasma kinetics, major metabolites identified, man
• ISSN: 0022-3549; 1520-6017
• DOI: 10.1002/jps.2600610514

Two studies of dl-2-(3-phenoxyphenyl)propionic acid or fenoprofen are described. In these studies, the pharmacokinetic parameters of fenoprofen administered orally and intravenously were compared first and then urine and plasma kinetics were compared. The results indicate that: (a) fenoprofen is rapidly and efficiently absorbed from the GI tract; (b) fenoprofen is extensively metabolized, and it and its metabolites are rapidly eliminated from the body by the kidneys; and (c) good agreement exists between plasma and urinary kinetics.