Comparative incorporation of S35 l-cystine and S35 sodium sulfate by normal and leukemic leukocytes

1. Certain differences are demonstrated in the metabolic turnover of l-cystine sulfur and inorganic sulfur by normal and leukemic leukocytes. These differences are apparent both in vivo and in vitro and may be associated with factors peculiar to the metabolism of leukemic leukocytes. 2. The incorpor...

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Bibliographic Details
Published in:Blood 1955-05, Vol.10 (5), p.458-466
Main Authors: WEISBERGER, A S, SUHRLAND, L G
Format: Article
Language:English
Subjects:
Cystine - metabolism
Humans
Leukemia - blood
Leukocytes
Old Medline
Sulfates
Sulfur
Sulfur Radioisotopes
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Summary:1. Certain differences are demonstrated in the metabolic turnover of l-cystine sulfur and inorganic sulfur by normal and leukemic leukocytes. These differences are apparent both in vivo and in vitro and may be associated with factors peculiar to the metabolism of leukemic leukocytes. 2. The incorporation of S35 l-cystine or S35 sodium sulfate by leukocytes appears to be associated primarily with the presence of immature granulocytes. 3. Both l-cystine (or l-cysteine) and sulfate may be of importance in the metabolism of leukocytes.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.v10.5.458.458