Effect of ischaemia and infarction on the metabolism and function of the isolated, perfused rat heart

The long-term effects of left coronary artery occlusion were studied on the metabolism and function of the isolated, perfused rat heart. Metabolic studies indicated anaerobiosis following occlusion, accompanied by a depression in ATP and CrP contents. Myocardial function was significantly depressed...

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Bibliographic Details
Published in:Cardiovascular research 1972-05, Vol.6 (3), p.284-294
Main Authors: BESTER, A. J., BAJUSZ, E., LOCHNER, A.
Format: Article
Language:English
Subjects:
Adenosine Diphosphate - analysis
Adenosine Monophosphate - analysis
Adenosine Triphosphate - analysis
Aldehyde-Lyases - blood
Animals
Carbon Dioxide - metabolism
Coronary Circulation
Coronary Vessels
Creatine Kinase - blood
Female
Glucose - metabolism
Glycogen - biosynthesis
Heart - physiology
Hydroxybutyrate Dehydrogenase - blood
In Vitro Techniques
L-Lactate Dehydrogenase - blood
Lactates - metabolism
Ligation
Muscle Contraction
Myocardium - enzymology
Myocardium - metabolism
Nitrogen - analysis
Oxygen Consumption
Pyruvates - metabolism
Rats
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Summary:The long-term effects of left coronary artery occlusion were studied on the metabolism and function of the isolated, perfused rat heart. Metabolic studies indicated anaerobiosis following occlusion, accompanied by a depression in ATP and CrP contents. Myocardial function was significantly depressed within 30 min, but returned to normal after one month.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/6.3.284