MYOCARDIAL METABOLISM AND DYNAMICS AFTER PRACTOLOL DURING LIGHT HALOTHANE ANAESTHESIA

In intact, steady-state, closed chest dogs, the effect of 0.625 and 1.25 mg/kg of the selective cardiac beta-adrenergic blocking drug, practolol, was tested during 1.2 m.a.c. halothane anaesthesia. Increases in the rate of rise of left ventricular pressure (dp/dt), left ventricular stroke work, mean...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1972-05, Vol.44 (5), p.437-445
Main Authors: Merdj, R.G., Basch, Sally
Format: Article
Language:English
Subjects:
Acetanilides - pharmacology
Adrenergic beta-Antagonists - pharmacology
Amino Alcohols - pharmacology
Anesthesia, General
Animals
Blood
Dogs
Fatty Acids, Nonesterified - metabolism
Halothane
Heart - drug effects
Heart Rate - drug effects
Heart Ventricles - drug effects
Hematocrit
Hydrogen-Ion Concentration
Lactates - metabolism
Male
Myocardium - metabolism
Oxygen Consumption
Propranolol - pharmacology
Sympatholytics - pharmacology
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Summary:In intact, steady-state, closed chest dogs, the effect of 0.625 and 1.25 mg/kg of the selective cardiac beta-adrenergic blocking drug, practolol, was tested during 1.2 m.a.c. halothane anaesthesia. Increases in the rate of rise of left ventricular pressure (dp/dt), left ventricular stroke work, mean aortic pressure, heart rate, and myocardial blood flow were observed. Myocardial oxygen, lactate and non-esterified fatty acid uptake increased also. In contrast to the effect of propranolol 0.25 mg/kg in a similar study, no evidence of cardiac depression was seen with practolol. It would appear that practolol is a more suitable beta-adrenergic blocking drug for use during halothane anaesthesia.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/44.5.437